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In vivo study on the expression pattern of resistin in patients with abdominal aortic aneurysm.
MedLine Citation:
PMID:  20810407     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
OBJECTIVE: To study the expression pattern of resistin in abdominal aortic aneurysms and to correlate its plasma levels to aneurysm size and statin therapy.
PATIENTS AND METHODS: From 25 patients on regular and 38 patients without statin therapy tissue specimen and plasma samples were obtained for analysis.
RESULTS: Demographic data, past medical history, and body mass index showed no significant differences between the statin and no statin group. Immunohistochemistry showed positive stainings for resistin in all sections and in part colocalization to CD 68 positive cells. Patients with large aneurysms showed significant correlation of C-reactive protein (CRP) and interleukin 10 (IL-10) levels; patients on statin medication had significantly lower plasma levels of resistin and CRP.
CONCLUSION: In contrast to IL-10 and CRP plasma levels of resistin are not correlated to aneurysm diameter; yet statin therapy results in decrease of resistin and CRP, suggesting an anti-inflammatory action in patients with abdominal aortic aneurysms (AAAs).
Authors:
Bernd M Muehling; Agnes Paintner; Nikolaus Marx; Thomas F E Barth; Christina Babiak; Karl H Orend
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Publication Detail:
Type:  Journal Article     Date:  2010-08-31
Journal Detail:
Title:  Vascular and endovascular surgery     Volume:  45     ISSN:  1938-9116     ISO Abbreviation:  Vasc Endovascular Surg     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136421     Medline TA:  Vasc Endovascular Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  63-8     Citation Subset:  IM    
Affiliation:
Department of Thoracic and Vascular Surgery, University of Ulm, Ulm, Germany. bernd.muehling@uniklinik-ulm.de
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