| In vivo space radiation-induced non-targeted responses: late effects on molecular signaling in mitochondria. | |
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MedLine Citation:
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PMID: 21166651 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The lack of clear knowledge about space radiation-induced biological effects has been singled out as the most important factor limiting the prediction of radiation risk associated with human space exploration. The expression of space radiation-induced non-targeted effects is thought to impact our understanding of the health risks associated with exposure to low fluences of particulate radiation encountered by astronauts during prolonged space travel. Following a brief review of radiation-induced bystander effects and the growing literature for the involvement of oxidative metabolism in their expression, we show novel data on the induction of in vivo non-targeted effects following exposure to 1100 MeV/nucleon titanium ions. Analyses of proteins by two-dimensional gel electrophoresis in non-targeted liver of cranially-irradiated Sprague Dawley rats revealed that the levels of key proteins involved in mitochondrial fatty acid metabolism are decreased. In contrast, those of proteins involved in various cellular defense mechanisms, including antioxidation, were increased. These data contribute to our understanding of the mechanisms underlying the biological responses to space radiation, and support the involvement of mitochondrial processes in the expression of radiation induced non-targeted effects. Significantly, they reveal the cross-talk between propagated stressful effects and induced adaptive responses. Together, with the accumulating data in the field, our results may help reduce the uncertainty in the assessment of the health risks to astronauts. They further demonstrate that 'network analyses' is an effective tool towards characterizing the signaling pathways that mediate the long-term biological effects of space radiation. |
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Authors:
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Mohit R Jain; Min Li; Wei Chen; Tong Liu; Sonia M de Toledo; Badri N Pandey; Hong Li; Bernard M Rabin; Edouard I Azzam |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Current molecular pharmacology Volume: 4 ISSN: 1874-4702 ISO Abbreviation: Curr Mol Pharmacol Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-06-15 Completed Date: 2011-09-30 Revised Date: 2012-04-23 |
Medline Journal Info:
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Nlm Unique ID: 101467997 Medline TA: Curr Mol Pharmacol Country: United Arab Emirates |
Other Details:
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Languages: eng Pagination: 106-14 Citation Subset: IM |
Affiliation:
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Department of Biochemistry and Molecular Biology, University of Medicine and Dentistry of New Jersey, New Jersey Medical School Cancer Center, Newark, NJ 07103, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bystander Effect / radiation effects* Cosmic Radiation* Humans Male Mass Spectrometry / methods Mitochondria / chemistry, physiology*, radiation effects*, ultrastructure Mitochondrial Proteins / analysis, radiation effects Radiation, Ionizing* Rats Rats, Sprague-Dawley Reactive Oxygen Species / metabolism Signal Transduction / radiation effects* Space Flight |
| Grant Support | |
ID/Acronym/Agency:
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P30 NS046593-09/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Mitochondrial Proteins; 0/Reactive Oxygen Species |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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