Document Detail


In Vivo Nanotoxicity Testing using the Zebrafish Embryo Assay.
MedLine Citation:
PMID:  24179674     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Nanoparticles are increasingly used for biomedical purposes. Many different diagnostic and therapeutic applications are envisioned for nanoparticles, but there are often also serious concerns regarding their safety. Given the fact that numerous new nanomaterials are being developed every day, and that not much is known about the long-term toxicological impact of exposure to nanoparticles, there is an urgent need to establish efficient methods for nanotoxicity testing. The zebrafish (Danio rerio) embryo assay has recently emerged as an interesting 'intermediate' method for in vivo nanotoxicity screening, enabling (semi-) high-throughput analyses in a system significantly more complex than cultured cells, but at the same time also less 'invasive' and less expensive than large-scale biocompatibility studies in mice or rats. The zebrafish embryo assay is relatively well-established in the environmental sciences, but it has not yet gained wide notice in the nanomedicine field. Using prototypic polymeric drug carriers, gold-based nanodiagnostics and nanotherapeutics, and iron oxide-based nanodiagnostics, we here show that toxicity testing using zebrafish embryos is easy, efficient and informative, and faithfully reflects, yet significantly extends, cell-based toxicity testing. We therefore expect that the zebrafish embryo assay will become a popular future tool for in vivo nanotoxicity screening.
Authors:
Larissa Y Rizzo; Susanne K Golombek; Marianne E Mertens; Yu Pan; Dominic Laaf; Janine Broda; Jabadurai Jayapaul; Diana Möckel; Vladimir Subr; Wim E Hennink; Gert Storm; Ulrich Simon; Willi Jahnen-Dechent; Fabian Kiessling; Twan Lammers
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Journal of materials chemistry. B, Materials for biology and medicine     Volume:  1     ISSN:  2050-750X     ISO Abbreviation:  J Mater Chem B Mater Biol Med     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-11-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101598493     Medline TA:  J Mater Chem B Mater Biol Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Experimental Molecular Imaging, University Clinic and Helmholtz Institute for Biomedical Engineering, RWTH - Aachen University, Aachen, Germany.
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Grant Support
ID/Acronym/Agency:
309495//European Research Council

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