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In Vivo Intra-articular Negative Pressure Wound Therapy Effect on Cartilage in a Goat Model.
MedLine Citation:
PMID:  21477533     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
This prospective, randomized, blinded pilot study determined if a difference was present in the histology and apoptotic rate of articular cartilage after application of a negative pressure wound therapy (NPWT) device to an uninjured joint surface compared to a control side using Capra hircus goats. The goats were euthanized at 3~or 7~days after surgery. The en bloc joint resection was divided into medial (direct sponge contact) and lateral compartments (no sponge contact; indirect NPWT). In the necropsied cartilage and menisci, there were no gross or histologic/morphometric differences identified by a blinded veterinary pathologist. The percentages of apoptotic and necrotic chondrocytes based on flow cytometry were not statistically different. This study demonstrated that there were no observable deleterious effects to uninjured cartilage from direct or indirect intra-articular NPWT placement. These data suggest that NPWT may be placed safely in an intra-articular position for up to 7~days. Further studies in humans are warranted.
Authors:
Maj Kenneth Bode; Maj Charles Haggerty; Lt Col J T Tokish; Lt Col Warren Kadrmas
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of surgical orthopaedic advances     Volume:  20     ISSN:  1548-825X     ISO Abbreviation:  J Surg Orthop Adv     Publication Date:  2011  
Date Detail:
Created Date:  2011-04-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101197881     Medline TA:  J Surg Orthop Adv     Country:  United States    
Other Details:
Languages:  eng     Pagination:  44-9     Citation Subset:  IM    
Affiliation:
2200 Bergquist Drive, Suite 1, SGOYO, Orthopaedics, Lackland AFB, TX 78236. Kenneth.bode@us.af.mil.
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