Document Detail


In Vivo Inflammation Does Not Impair ABCA1-Mediated Cholesterol Efflux Capacity of HDL.
MedLine Citation:
PMID:  22611487     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
HDL provides atheroprotection by facilitating cholesterol efflex from lipid-laden macrophages in the vessel wall. In vitro studies have suggested impaired efflux capacity of HDL following inflammatory changes. We assessed the impact of acute severe sepsis and mild chronic inflammatory disease on the efflux capacity of HDL. We hypothesize that a more severe inflammatory state leads to stronger impaired cholesterol efflux capacity. Using lipid-laden THP1 cells and fibroblasts we were able to show that efflux capacity of HDL from both patients with severe sepsis or with Crohn's disease (active or in remission), either isolated using density gradient ultracentrifugation or using apoB precipitation, was not impaired. Yet plasma levels of HDL cholesterol and apoA-I were markedly lower in patients with sepsis. Based on the current observations we conclude that inflammatory disease does not interfere with the capacity of HDL to mediate cholesterol efflux. Our findings do not lend support to the biological relevance of HDL function changes in vitro.
Authors:
Remco Franssen; Alinda W M Schimmel; Sander I van Leuven; Simone C S Wolfkamp; Erik S G Stroes; Geesje M Dallinga-Thie
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Publication Detail:
Type:  Journal Article     Date:  2012-04-24
Journal Detail:
Title:  Cholesterol     Volume:  2012     ISSN:  2090-1291     ISO Abbreviation:  Cholesterol     Publication Date:  2012  
Date Detail:
Created Date:  2012-05-21     Completed Date:  2012-08-23     Revised Date:  2013-03-04    
Medline Journal Info:
Nlm Unique ID:  101540641     Medline TA:  Cholesterol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  610741     Citation Subset:  -    
Affiliation:
Department of Vascular Medicine, Academic Medical Center Amsterdam, 1105 AZ Amsterdam, The Netherlands.
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