| In vivo gene delivery by nonviral vectors: overcoming hurdles? | |
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MedLine Citation:
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PMID: 22525514 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The promise of cancer gene therapeutics is hampered by difficulties in the in vivo delivery to the targeted tumor cells, and systemic delivery remains to be the biggest challenge to be overcome. Here, we concentrate on systemic in vivo gene delivery for cancer therapy using nonviral vectors. In this review, we summarize the existing delivery barriers together with the requirements and strategies to overcome these problems. We will also introduce the current progress in the design of nonviral vectors, and briefly discuss their safety issues. |
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Authors:
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Yuan Zhang; Andrew Satterlee; Leaf Huang |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2012-04-24 |
Journal Detail:
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Title: Molecular therapy : the journal of the American Society of Gene Therapy Volume: 20 ISSN: 1525-0024 ISO Abbreviation: Mol. Ther. Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-07-04 Completed Date: 2013-01-16 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 100890581 Medline TA: Mol Ther Country: United States |
Other Details:
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Languages: eng Pagination: 1298-304 Citation Subset: IM |
Affiliation:
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Division of Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7571, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Gene Transfer Techniques* Genetic Therapy* Genetic Vectors* Humans Liposomes / therapeutic use Nanoparticles RNA Interference RNA, Small Interfering / therapeutic use* |
| Grant Support | |
ID/Acronym/Agency:
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CA129835/CA/NCI NIH HHS; CA149361/CA/NCI NIH HHS; CA151455/CA/NCI NIH HHS; CA151652/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Liposomes; 0/RNA, Small Interfering |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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