Document Detail


In Vivo Experimental Aneurysm Embolization in a Swine Model with a Liquid-to-Solid Gelling Polymer System: Initial Biocompatibility and Delivery Strategy Analysis.
MedLine Citation:
PMID:  22120570     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: Current treatments for cerebral aneurysms are far from ideal. Platinum coils are prone to compaction, and currently used liquid embolics are delivered with angiotoxic agents. This work presents initial in vivo studies of a novel liquid-to-solid gelling polymer system (PPODA-QT), focusing on biocompatibility and effective delivery strategies. METHODS: PPODA-QT was used to embolize surgically created lateral wall carotid artery aneurysms in swine using three delivery strategies. Group 1 aneurysms were completely filled with PPODA-QT (n=5), Group 2 aneurysms were sub-completely (80-90%) filled (n=3), and Group 3 aneurysms underwent 3D coil placement followed by polymer embolization (n=3). The study was designed such that three animals per treatment group survived to one month. RESULTS: The Group 1 delivery strategy of (100% filling) resulted in survival of 3/5 animals. This strategy lead to aneurysm stretching, which resulted model failure in 2/5 animals. Group 2 aneurysms, while initially <100% filled with the polymer, displayed robust NI tissue coverage and complete obliteration after one month. Group 3 aneurysms showed less prominent NI tissue coverage as well as 2/3 instances of excess polymer found in the parent vessel. The PPODA-QT material showed good biocompatibility with vascular tissue in all animals at one month. CONCLUSION: This small scale pilot study highlighted first-time in vivo use of PPODA-QT as an embolic agent for aneurysm treatment. Filling aneurysms to 80-90% capacity proved to be a safe and effective delivery strategy, while PPODA-QT showed excellent biocompatibility. This study indicates that future investigation of PPODA-QT for aneurysm embolization is warranted, as it may prove to be a viable alternative to current embolic materials.
Authors:
Celeste Riley; Mark C Preul; William D Bichard; Brent L Vernon
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-11-1
Journal Detail:
Title:  World neurosurgery     Volume:  -     ISSN:  1878-8750     ISO Abbreviation:  -     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101528275     Medline TA:  World Neurosurg     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011. Published by Elsevier Inc.
Affiliation:
Center for Interventional Biomaterials, School of Biological and Health Systems Engineering, Arizona State University, Tempe, AZ.
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