Document Detail


In vivo determination of collecting lymphatic vessel permeability to albumin: a role for lymphatics in exchange.
MedLine Citation:
PMID:  19917564     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
While it is well established that the lymphatic vasculature is central to fluid and solute homeostasis, how it accomplishes this task is not well defined. To clarify the basic mechanisms underlying basal fluid and solute homeostasis, we assessed permeability to rat serum albumin (P(RSA)(s)) in mesenteric collecting lymphatic vessels and venules of juvenile male rats. Using the quantitative microfluorometric technique originally developed for blood capillaries, we tested the hypothesis that as a consequence of venules and collecting lymphatics sharing a common embryological origin, their P(RSA)(s) would not differ significantly. Supporting our hypothesis, the median collecting lymphatic P(RSA)(s) (3.5 +/- 1.0 x 10(7) cm s(-1), N = 22) did not differ significantly from the median venular P(RSA)(s) (4.0 +/- 1.0 x 10(7) cm s(-1), N = 8, P = 0.61). For collecting lymphatics the diffusive permeability (P(d) = 2.5 x 10(7) cm s(-1)) was obtained from the relationship of apparent P(RSA)(s) and pressure. While the measured P(RSA)(s), P(d) and estimated hydraulic conductivity of collecting lymphatics and venules were similar, the contribution of convective coupling differs as a result of the higher hydrostatic pressure experienced by venules relative to collecting lymphatics in vivo. In summary, the data demonstrate the capacity for collecting lymphatics to act as exchange vessels, able to extravasate solute and filter fluid. As a consequence these data provide experimental support for the theory that prenodal lymphatic vessels concentrate intraluminal protein.
Authors:
Joshua P Scallan; Virginia H Huxley
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2009-11-16
Journal Detail:
Title:  The Journal of physiology     Volume:  588     ISSN:  1469-7793     ISO Abbreviation:  J. Physiol. (Lond.)     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-01-04     Completed Date:  2010-03-25     Revised Date:  2013-05-31    
Medline Journal Info:
Nlm Unique ID:  0266262     Medline TA:  J Physiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  243-54     Citation Subset:  IM    
Affiliation:
Department of Medical Pharmacology & Physiology, University of Missouri School of Medicine, Columbia, MO 65212, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Computer Simulation
Lymphatic Vessels / metabolism*
Male
Models, Biological*
Permeability
Rats
Rats, Sprague-Dawley
Serum Albumin / metabolism*
Grant Support
ID/Acronym/Agency:
HL078816/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Serum Albumin
Comments/Corrections

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