Document Detail


In vivo confocal microscopic evaluation of corneal wound healing after femtosecond laser-assisted keratoplasty.
MedLine Citation:
PMID:  22329795     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND OBJECTIVE: To evaluate corneal wound healing after femtosecond laser-assisted keratoplasty (FLAK) using in vivo confocal microscopy (IVCM).
PATIENTS AND METHODS: Prospective, interventional, consecutive case series of 17 eyes after mushroom-shaped FLAK. IVCM was performed preoperatively and at 1, 3, 6, and 12 months postoperatively to assess wound healing.
RESULTS: Mean keratocyte activation grade increased from preoperative levels to 1 month postoperatively in both the central (0.41 ± 0.62 to 1.73 ± 1.03) and peripheral (0.47 ± 0.52 to 1.57 ± 1.09) cornea, then gradually decreased through 12 months. Dendritic cells increased from preoperatively to 1 month postoperatively in both the central (0.71 ± 0.83 to 1.33 ± 0.98) and peripheral (0.79 ± 0.70 to 1.42 ± 0.90) cornea, then gradually decreased until 6 months postoperatively. Stromal reinnervation was 1 month postoperatively in 8 patients (50%). By 12 months, sub-epithelial nerves were observed centrally in 5 patients (45.5%).
CONCLUSION: IVCM after FLAK shows an initial increase in keratocyte activation and dendritic cells that decrease over time. Corneal reinnervation is seen as early as 1 month postoperatively.
Authors:
Roni M Shtein; Kurt H Kelley; David C Musch; Alan Sugar; Shahzad I Mian
Related Documents :
11999665 - Effects of pravastatin on exercise electrocardiography test performance and cardiovascu...
16923435 - Multifactorial intervention to prevent recurrent cardiovascular events in patients 75 y...
10889125 - Long-term effects on clinical outcomes of aggressive lowering of low-density lipoprotei...
8430625 - Design and baseline results of the scandinavian simvastatin survival study of patients ...
17063535 - Influence of age on the prescription of vitamin k antagonists in outpatients with perma...
10361755 - True status of smear-positive pulmonary tuberculosis defaulters in malawi.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-02-16
Journal Detail:
Title:  Ophthalmic surgery, lasers & imaging : the official journal of the International Society for Imaging in the Eye     Volume:  43     ISSN:  1938-2375     ISO Abbreviation:  Ophthalmic Surg Lasers Imaging     Publication Date:    2012 May-Jun
Date Detail:
Created Date:  2012-05-16     Completed Date:  2012-08-07     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  101155780     Medline TA:  Ophthalmic Surg Lasers Imaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  205-13     Citation Subset:  IM    
Copyright Information:
Copyright 2012, SLACK Incorporated.
Affiliation:
Department of Ophthalmology and Visual Sciences, Kellogg Eye Center, Ann Arbor, MI 48105, USA. ronim@med.umich.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Cornea / physiology*
Corneal Keratocytes / physiology
Corneal Stroma / innervation
Corneal Transplantation / methods*
Dendritic Cells / cytology
Female
Fuchs' Endothelial Dystrophy / physiopathology,  surgery*
Humans
Keratoconus / physiopathology,  surgery*
Laser Therapy / methods*
Lasers, Excimer
Male
Microscopy, Confocal*
Middle Aged
Nerve Regeneration / physiology
Ophthalmic Nerve / physiology
Prospective Studies
Wound Healing / physiology*
Young Adult
Grant Support
ID/Acronym/Agency:
EY017885/EY/NEI NIH HHS; K23 EY017885/EY/NEI NIH HHS; UL1RR024986/RR/NCRR NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Cumulative incidence of pandemic influenza A (H1N1) 2009 by a community-based serological cohort stu...
Next Document:  Adsorption and Desorption Properties of Macroporous Resins for Anthocyanins from the Calyx Extract o...