| In Vivo Computed Tomography as a Research Tool to Investigate Asthma and COPD: Where Do We Stand? | |
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MedLine Citation:
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PMID: 22287977 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Computed tomography (CT) is a clinical tool widely used to assess and followup asthma and chonic obstructive pulmonary disease (COPD) in humans. Strong efforts have been made the last decade to improve this technique as a quantitative research tool. Using semiautomatic softwares, quantification of airway wall thickness, lumen area, and bronchial wall density are available from large to intermediate conductive airways. Skeletonization of the bronchial tree can be built to assess its three-dimensional geometry. Lung parenchyma density can be analysed as a surrogate of small airway disease and emphysema. Since resident cells involve airway wall and lung parenchyma abnormalities, CT provides an accurate and reliable research tool to assess their role in vivo. This litterature review highlights the most recent advances made to assess asthma and COPD with CT, and also their drawbacks and the place of CT in clarifying the complex physiopathology of both diseases. |
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Authors:
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Gaël Dournes; Michel Montaudon; Patrick Berger; François Laurent |
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Publication Detail:
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Type: Journal Article Date: 2012-01-11 |
Journal Detail:
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Title: Journal of allergy Volume: 2012 ISSN: 1687-9791 ISO Abbreviation: J Allergy (Cairo) Publication Date: 2012 |
Date Detail:
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Created Date: 2012-01-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101535174 Medline TA: J Allergy (Cairo) Country: United States |
Other Details:
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Languages: eng Pagination: 972479 Citation Subset: - |
Affiliation:
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Department of Thoracic and Cardiovascular Imaging, CHU Bordeaux, Avenue de Magellan, 33604 Pessac, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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