| In Vivo Assessment of Oxygen Consumption via Deuterium Magnetic Resonance. | |
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MedLine Citation:
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PMID: 21445787 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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We present a novel approach to simultaneously measure, in vivo, noninvasively, glucose and oxygen consumption via Deuterium Magnetic Resonance (DMR). Mice are administered deuteriated glucose by intravenous injection. The rate of formation of nascent (deuteriated) mitochondrial water is then measured via DMR. The rate of glucose metabolism and oxygen utilization is assessed by tracking their separate peaks in DMR spectra during dynamic scanning. Further studies will aim to validate these results by comparison with in vivo (17)O-MRI (mitochondrial function), (13)C-MRI and (19)FDG-PET (glucose metabolism) and ex vivo 1H- and 2H-MR, as well as mass spectrometry.(1). |
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Authors:
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Gheorghe D Mateescu; Allen Ye; Chris A Flask; Bernadette Erokwu; Jeffrey L Duerk |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Advances in experimental medicine and biology Volume: 915 ISSN: 0065-2598 ISO Abbreviation: Adv. Exp. Med. Biol. Publication Date: 2011 |
Date Detail:
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Created Date: 2011-03-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0121103 Medline TA: Adv Exp Med Biol Country: United States |
Other Details:
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Languages: eng Pagination: 193-9 Citation Subset: IM |
Affiliation:
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Case Center for Imaging Research, Case Western Reserve University, Cleveland, OH, 44106, USA, gdm2@case.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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