Document Detail

In vivo assessment of chitosan/β-glycerophosphate as a new liquid embolic agent.
MedLine Citation:
PMID:  21561564     Owner:  NLM     Status:  MEDLINE    
We sought to assess the feasibility of using thermosensitive chitosan/β-glycerophosphate forembolotherapy. The renal arteries in nine rabbits were embolized with chitosan/β-glycero-phosphate. The animals were studied angiographically and sacrificed at one week (n = 3), four weeks (n = 3), and eight weeks (n = 3) after embolotherapy. Histology was obtained at these three time points. Delivery of chitosan/β-glycerophosphate was successful in all cases. Complete occlusion was achieved in all cases. No recanalization was observed in the follow-up angiograms. No untoward inflammatory reactions were observed in the target renal arteries and infarcted kidneys during the histological examinations. Our preliminary feasibility evaluation in rabbit renal arteries indicates that C/GP is a satisfactory embolization agent.
Y Wang; N Xu; Q Luo; Y Li; L Sun; H Wang; K Xu; B Wang; Y Zhen
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Publication Detail:
Type:  Journal Article     Date:  2011-04-29
Journal Detail:
Title:  Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences     Volume:  17     ISSN:  1591-0199     ISO Abbreviation:  Interv Neuroradiol     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-05-12     Completed Date:  2011-07-12     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  9602695     Medline TA:  Interv Neuroradiol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  87-92     Citation Subset:  IM    
First Hospital of Jilin University, Jilin University, Changchun, Jilin, China.
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MeSH Terms
Angiography, Digital Subtraction
Chitosan / chemistry,  pharmacology*
Embolization, Therapeutic / methods*
Glycerophosphates / chemistry,  pharmacology*
Hydrophobic and Hydrophilic Interactions
Injections, Intra-Arterial
Models, Animal
Renal Artery / pathology,  radiography*
Reg. No./Substance:
0/Glycerophosphates; 9012-76-4/Chitosan; WWH06G87W6/beta-glycerophosphoric acid

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