| In vitro starch digestion kinetics, corrected for estimated gastric emptying, predict portal glucose appearance in pigs. | |
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MedLine Citation:
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PMID: 20444950 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In vitro starch digestion is used for predicting the in vivo glucose response, but their relationship has not been defined thoroughly. To clarify, in vitro starch digestion using a modified Englyst-assay was compared to portal glucose appearance in pigs. Four portal vein-catheterized pigs (43.2 +/- 4.8 kg body weight) were fed 4 diets containing 70% purified starch ranging from slowly to rapidly digestible [maximal rate of in vitro digestion (%)/min: 0.22 (slowly), 0.38, 0.73, and 1.06 (rapidly)] for 7-d periods in a 4 x 4 Latin square. In vivo (R2 = 0.964) and in vitro (R2 = 0.998) data were modeled using a Chapman-Richards model that accurately described the sigmoidal glucose-release profiles. Across samples, the extent of glucose recovered was less in vivo than in vitro (69 vs. 42% of starch). The rate of glucose release adjusted for plateau effects was lower in vivo (0.35 vs. 0.89%/min), whereas the shape parameter adjusted for plateau effects (sigmoidal modifier) was higher in vivo (37.9 vs. 13.7). Consequently, peak glucose release in vivo occurred 69 min postprandial, whereas it occurred only 6 min into the second stage of digestion in vitro. Cumulative portal glucose appearance was strongly related (R2 = 0.89; P < 0.001) to in vitro glucose release, although a nonlinear bias was observed. After correcting in vitro release with predicted gastric emptying, the relationship improved and became linear (R2 = 0.95; P < 0.001). In conclusion, in vitro starch digestion kinetics predict portal glucose appearance up to 8 h postprandial accurately provided that in vitro data are corrected for gastric emptying. |
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Authors:
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Theo A T G van Kempen; Prajwal R Regmi; J Jacques Matte; Ruurd T Zijlstra |
Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't Date: 2010-05-05 |
Journal Detail:
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Title: The Journal of nutrition Volume: 140 ISSN: 1541-6100 ISO Abbreviation: J. Nutr. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-21 Completed Date: 2010-07-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0404243 Medline TA: J Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 1227-33 Citation Subset: IM |
Affiliation:
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Provimi Research and Innovation Centre, B-1932 Brussels, Belgium. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Digestion* Gastric Emptying* Glucose / metabolism* Kinetics Starch / metabolism* Swine / metabolism, physiology* |
| Chemical | |
Reg. No./Substance:
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50-99-7/Glucose; 9005-25-8/Starch |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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