| In vitro-generated DC with tolerogenic functions: perspectives for in vivo cellular therapy. | |
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MedLine Citation:
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PMID: 20941608 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dendritic cells (DCs) have a central role in immune regulation and serve as an essential link between innate and adaptive immunity. Their broad range of powerful immune stimulatory as well as regulatory functions has made DCs a target for vaccine development strategies. One approach to promote the tolerogenicity of DCs is to suppress their maturation by pharmacological agents, including the glucocorticoid dexamethasone. In this chapter, we describe methods to generate tolerogenic Dex-DC derived from either human peripheral blood monocytes or rat bone marrow cells. |
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Authors:
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Cees van Kooten; Kyra A Gelderman |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Methods in molecular biology (Clifton, N.J.) Volume: 677 ISSN: 1940-6029 ISO Abbreviation: Methods Mol. Biol. Publication Date: 2011 |
Date Detail:
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Created Date: 2010-10-13 Completed Date: 2011-02-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9214969 Medline TA: Methods Mol Biol Country: United States |
Other Details:
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Languages: eng Pagination: 149-59 Citation Subset: IM |
Affiliation:
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Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands. kooten@lumc.nl |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bone Marrow Cells / drug effects*, immunology Cell Differentiation / physiology Cells, Cultured Cytokines / pharmacology Dendritic Cells / drug effects*, immunology Dexamethasone / pharmacology Humans Immune Tolerance / drug effects* Immunosuppressive Agents / pharmacology Internationality Organic Chemicals / toxicity Rats Tissue Therapy / utilization* |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 0/Immunosuppressive Agents; 0/Organic Chemicals; 0/Tolerogen; 50-02-2/Dexamethasone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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