Document Detail


In vitro dermal absorption of di(2-ethylhexyl) adipate (DEHA) in a roll-on deodorant using human skin.
MedLine Citation:
PMID:  23356645     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In vitro dermal absorption experiments were conducted using a roll-on deodorant that contains 1.56% di(2-ethylhexyl) adipate (DEHA), a plasticizer widely used in consumer products. Human skin specimens were fitted in Bronaugh flow-through Teflon diffusion cells. The diffusion cells were maintained at 32 °C to reflect the skin temperature. Two amounts (low dose: 5 mg of the product; high dose: 100 mg) were applied, in triplicate, each on four different human skins. DEHA was determined in the receiver solution at 6-h intervals, using headspace solid-phase microextraction gas chromatography-mass spectrometry (GC-MS). After 24 h, the experiment was terminated and masses of DEHA in the skin depot, skin wash, and upper and lower chambers of the diffusion cell were determined. A significant portion of applied DEHA, 28% in the low amount application and 34% in the high one, was found in the skin depot. In comparison, only 0.04% and 0.002% of applied DEHA were found in the receiver solutions for the low and high doses, respectively. Under our experimental conditions, an apparent steady-state flux of low DEHA mass penetrating from skin into the receiver solution was observed with a penetration rate of 2.2 ng/cm(2)/h for both the low and high doses. The average mass recovery was 81% for the low dose application and 56% for the high dose.
Authors:
Simon Ningsun Zhou; Richard P Moody; Bio Aikawa; Anna Yip; Bing Wang; Jiping Zhu
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Journal of toxicology and environmental health. Part A     Volume:  76     ISSN:  1528-7394     ISO Abbreviation:  J. Toxicol. Environ. Health Part A     Publication Date:  2013  
Date Detail:
Created Date:  2013-01-29     Completed Date:  2013-03-26     Revised Date:  2013-11-13    
Medline Journal Info:
Nlm Unique ID:  100960995     Medline TA:  J Toxicol Environ Health A     Country:  England    
Other Details:
Languages:  eng     Pagination:  157-66     Citation Subset:  IM    
Affiliation:
Exposure and Biomonitoring Division, Health Canada, Ottawa, Ontario, Canada.
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MeSH Terms
Descriptor/Qualifier:
Adipates / pharmacokinetics*
Administration, Cutaneous
Consumer Product Safety
Deodorants / pharmacokinetics*
Gas Chromatography-Mass Spectrometry
Humans
Plasticizers
Skin / metabolism*
Skin Absorption*
Time Factors
Chemical
Reg. No./Substance:
0/Adipates; 0/Deodorants; 0/Plasticizers; 2BD76YG9SI/dioctyl adipate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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