| In vitro characterization of cisplatin-loaded superabsorbent polymer microspheres designed for chemoembolization. | |
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MedLine Citation:
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PMID: 20417118 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To find appropriate contrast media to load cisplatin into superabsorbent polymer (SAP) and to analyze the absorption and elution kinetics of cisplatin to and from SAP. MATERIALS AND METHODS: Three contrast media-ioxaglic acid 320 mg/mL, iohexol 300 mg/mL, and iopamidol 300 mg/mL-were tested for solubility of a new highly soluble cisplatin powder. The appropriate concentrations of cisplatin were predetermined according to the solubility in each contrast medium. For each concentration, we assessed the cisplatin elution kinetics with an atomic absorption spectrophotometer. The SAP particle diameters (106-150 microm dry size) before and after drug elution were also measured. RESULTS: The concentrations of cisplatin were predetermined as 2.5 mg/mL in ioxaglic acid, 2.5 mg/mL in iohexol, and 5.0 mg/mL in iohexol. At these concentrations, 100 mg of SAP carried 5 mg, 25 mg, and 50 mg of cisplatin dissolved in ioxaglic acid (2.5 mg/mL) and iohexol (2.5 mg/mL and 5.0 mg/mL), respectively. Cisplatin-loaded SAP in ioxaglic acid and iohexol exhibited similar elution profiles, with cisplatin fractions of 15%, 40%, 70%, and 95% at 1, 3, 6, and 24 hours, respectively. By drug elution, the mean particle diameter changed from 0.31 mm to 0.61 mm in ioxaglic acid (2.5 mg/mL), from 0.54 mm to 0.60 mm in iohexol 2.5 mg/mL, and from 0.63 mm to 0.59 mm in iohexol 5.0 mg/mL. CONCLUSIONS: SAP was confirmed to absorb and elute cisplatin within 24 hours. When mixed with iohexol, SAP carried a ten times larger dose of cisplatin and expanded twice as large as when mixed with ioxaglic acid. Cisplatin-loaded SAP may have potential as a drug delivery system for the clinical treatment of liver tumors. |
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Authors:
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Noboru Maeda; Keigo Osuga; Hiroki Higashihara; Koji Mikami; Kaname Tomoda; Shinichi Hori; Tetsuro Nakazawa; Hironobu Nakamura |
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Publication Detail:
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Type: Journal Article Date: 2010-04-22 |
Journal Detail:
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Title: Journal of vascular and interventional radiology : JVIR Volume: 21 ISSN: 1535-7732 ISO Abbreviation: J Vasc Interv Radiol Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-24 Completed Date: 2010-09-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9203369 Medline TA: J Vasc Interv Radiol Country: United States |
Other Details:
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Languages: eng Pagination: 877-81 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 SIR. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Diagnostic and Interventional Radiology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka Suita, Osaka 565-0871, Japan. n-maeda@radiol.med.osaka-u.ac.jp |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Absorption Cisplatin / administration & dosage, chemistry* Drug Carriers / chemistry* Drug Compounding / methods Embolization, Therapeutic / methods* Hemostatics / administration & dosage, chemistry* Kinetics Microspheres Polymers / chemistry* |
| Chemical | |
Reg. No./Substance:
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0/Drug Carriers; 0/Hemostatics; 0/Polymers; 15663-27-1/Cisplatin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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