Document Detail


In vitro characterization of bicuspid aortic valve hemodynamics using particle image velocimetry.
MedLine Citation:
PMID:  22318396     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The congenital bicuspid aortic valve (BAV) is associated with increased leaflet calcification, ascending aortic dilatation, aortic stenosis (AS) and regurgitation (AR). Although underlying genetic factors have been primarily implicated for these complications, the altered mechanical environment of BAVs could potentially accelerate these pathologies. The objective of the current study is to characterize BAV hemodynamics in an in vitro system. Two BAV models of varying stenosis and jet eccentricity and a trileaflet AV (TAV) were constructed from excised porcine AVs. Particle Image Velocimetry (PIV) experiments were conducted at physiological flow and pressure conditions to characterize fluid velocity fields in the aorta and sinus regions, and ensemble averaged Reynolds shear stress and 2D turbulent kinetic energy were calculated for all models. The dynamics of the BAV and TAV models matched the characteristics of these valves which are observed clinically. The eccentric and stenotic BAV showed the strongest systolic jet (V = 4.2 m/s), which impinged on the aortic wall on the non-fused leaflet side, causing a strong vortex in the non-fused leaflet sinus. The magnitudes of TKE and Reynolds stresses in both BAV models were almost twice as large as comparable values for TAV, and these maximum values were primarily concentrated around the central jet through the valve orifice. The in vitro model described here enables detailed characterization of BAV flow characteristics, which is currently challenging in clinical practice. This model can prove to be useful in studying the effects of altered BAV geometry on fluid dynamics in the valve and ascending aorta. These altered flows can be potentially linked to increased calcific responses from the valve endothelium in stenotic and eccentric BAVs, independent of concomitant genetic factors.
Authors:
Neelakantan Saikrishnan; Choon-Hwai Yap; Nicole C Milligan; Nikolay V Vasilyev; Ajit P Yoganathan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-02-09
Journal Detail:
Title:  Annals of biomedical engineering     Volume:  40     ISSN:  1573-9686     ISO Abbreviation:  Ann Biomed Eng     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-06-28     Completed Date:  2012-10-31     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  0361512     Medline TA:  Ann Biomed Eng     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1760-75     Citation Subset:  IM    
Affiliation:
Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology & Emory University, Atlanta, GA, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Aorta* / pathology,  physiopathology
Hemodynamics*
Hemorheology*
Humans
Mitral Valve* / pathology,  physiopathology
Mitral Valve Stenosis* / pathology,  physiopathology
Models, Cardiovascular*
Swine
Comments/Corrections
Erratum In:
Ann Biomed Eng. 2012 Aug;40(8):1776

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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