Document Detail


In vitro bioavailability of iron from the heme analogue sodium iron chlorophyllin.
MedLine Citation:
PMID:  20025224     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The use of heme analogues from vegetable origin could provide an alternative iron source of potentially high bioavailability. Sodium iron chlorophyllin is a water-soluble semisynthetic chlorophyll derivative where the magnesium in the porphyrin ring has been substituted by iron. We have used an in vitro model that combines gastric and intestinal digestion followed by intestinal iron uptake in Caco-2 cells to determine the bioavailability of iron from sodium iron chlorophyllin. Our results demonstrate that sodium iron chlorophyllin is stable under simulated gastrointestinal conditions and is able to deliver bioavailable iron to Caco-2 cells. Similar to the heme, the bioavailability of iron from sodium iron chlorophyllin is dependent on the food matrix, and it was inhibited by calcium. Potentially, sodium iron chlorophyllin could be used as an iron fortificant from vegetable origin with high bioavailability.
Authors:
Silvia Miret; Serpil Tascioglu; Monique van der Burg; Leon Frenken; Werner Klaffke
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of agricultural and food chemistry     Volume:  58     ISSN:  1520-5118     ISO Abbreviation:  J. Agric. Food Chem.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-01-20     Completed Date:  2010-03-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0374755     Medline TA:  J Agric Food Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1327-32     Citation Subset:  IM    
Affiliation:
Unilever R&D Vlaardingen, Olivier van Noortlaan, The Netherlands. Silvia.Miret-Catalan@unilever.com
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MeSH Terms
Descriptor/Qualifier:
Biological Availability
Caco-2 Cells
Chlorophyllides / pharmacokinetics*
Digestion*
Humans
Intestinal Absorption*
Iron / pharmacokinetics*
Models, Biological
Chemical
Reg. No./Substance:
0/Chlorophyllides; 15611-43-5/chlorophyllin; 7439-89-6/Iron

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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