| In-Vitro Antagonistic Characteristics of Crude Aqueous and Methanolic Extracts of Garcinia kola (Heckel) Seeds against Some Vibrio Bacteria. | |
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MedLine Citation:
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PMID: 21441874 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The methanolic and aqueous extracts of Garcinia kola seeds were screened for their anti-Vibrio activities against 50 Vibrio isolates obtained from wastewater final effluents in the Eastern Cape Province, South Africa. The crude extracts at 10 mg/mL exhibited appreciable inhibitory activities against most of the test Vibrio isolates, with zones of inhibition ranging from 10-19 mm for methanol extract and 8-15 mm for the aqueous extracts. The minimum inhibitory concentrations (MIC) of the methanol extract varied from 0.313 to 2.5 mg/mL while that for the aqueous extract was 10 mg/mL for all the susceptible Vibrio isolates. Rate of kill assay of the methanolic extracts against three selected Vibrio species showed bacteriostatic activities against all of them achieving 58% and 60% (Vibrio vulnificus AL042); 68% and 69% (Vibrio parahaemolyticus AL049); and 70% and 78% (Vibrio fluvialis AL040) killing of the test bacteria at 3× and 4 ×MIC values, respectively, after 2 h exposure time. We conclude that Garcinia kola seeds hold promise as a potential source of therapeutic compounds of relevance in Vibrio infections management. |
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Authors:
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Dambudzo Penduka; Omobola O Okoh; Anthony I Okoh |
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Publication Detail:
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Type: Journal Article Date: 2011-03-24 |
Journal Detail:
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Title: Molecules (Basel, Switzerland) Volume: 16 ISSN: 1420-3049 ISO Abbreviation: Molecules Publication Date: 2011 |
Date Detail:
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Created Date: 2011-03-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100964009 Medline TA: Molecules Country: Switzerland |
Other Details:
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Languages: eng Pagination: 2754-65 Citation Subset: IM |
Affiliation:
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Applied and Environmental Microbiology Research Group (AEMREG), Department of Biochemistry and Microbiology, University of Fort Hare, Alice, South Africa. aokoh@ufh.ac.za. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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