| In Situ Enhancement of Pulmonary Surfactant Function Using Temporary Flow Reversal. | |
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MedLine Citation:
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PMID: 21998268 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Acute respiratory distress syndrome (ARDS) is a pulmonary disease with approximately 40% mortality rate and 75,000 deaths annually in the US. Mechanical ventilation restores airway patency and gas transport, but leads to ventilator-induced lung injury (VILI). Furthermore, surfactant replacement therapy (SRT) is ineffective due to surfactant delivery difficulties and deactivation by vascular proteins leaking into the airspace. Here we demonstrate that surfactant function can be substantially improved (up to 50%) in situ in an in vitro pulmonary airway model by using unconventional flows that incorporate a short-term retraction of the air-liquid interface, leading to a net decrease in cellular damage. Computational fluid dynamic simulations provide insight into this method and demonstrate the physicochemical hydrodynamic foundation for the improved surfactant micro-scale transport and mobility. These studies may provide a starting point for developing novel ventilation waveforms to improve surfactant function in edematous airways. |
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Authors:
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Henry William Glindmeyer; Bradford Julian Smith; Donald P Gaver |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-13 |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: - ISSN: 1522-1601 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1Tulan University. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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