Document Detail


In situ enhancement of pulmonary surfactant function using temporary flow reversal.
MedLine Citation:
PMID:  21998268     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Acute respiratory distress syndrome is a pulmonary disease with a mortality rate of ∼40% and 75,000 deaths annually in the United States. Mechanical ventilation restores airway patency and gas transport but leads to ventilator-induced lung injury. Furthermore, surfactant replacement therapy is ineffective due to surfactant delivery difficulties and deactivation by vascular proteins leaking into the airspace. Here, we demonstrated that surfactant function can be substantially improved (up to 50%) in situ in an in vitro pulmonary airway model using unconventional flows that incorporate a short-term retraction of the air-liquid interface, leading to a net decrease in cellular damage. Computational fluid dynamic simulations provided insights into this method and demonstrated the physicochemical hydrodynamic foundation for the improved surfactant microscale transport and mobility. This study may provide a starting point for developing novel ventilation waveforms to improve surfactant function in edematous airways.
Authors:
Henry W Glindmeyer; Bradford J Smith; Donald P Gaver
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2011-10-13
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  112     ISSN:  1522-1601     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2011-12-23     Completed Date:  2012-08-21     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  149-58     Citation Subset:  IM    
Affiliation:
Department of Biomedical Engineering, Tulane University, New Orleans, Louisiana 70118, USA.
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MeSH Terms
Descriptor/Qualifier:
Cell Death / drug effects,  physiology
Cell Line
Cell Line, Tumor
Computational Biology / methods
Humans
Hydrodynamics*
Pulmonary Surfactants* / administration & dosage
Surface Properties / drug effects
Grant Support
ID/Acronym/Agency:
R01-HL-81266/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Pulmonary Surfactants
Comments/Corrections
Comment In:
J Appl Physiol (1985). 2012 Feb;112(3):333-4   [PMID:  22134688 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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