| In situ enhancement of pulmonary surfactant function using temporary flow reversal. | |
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MedLine Citation:
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PMID: 21998268 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Acute respiratory distress syndrome is a pulmonary disease with a mortality rate of ∼40% and 75,000 deaths annually in the United States. Mechanical ventilation restores airway patency and gas transport but leads to ventilator-induced lung injury. Furthermore, surfactant replacement therapy is ineffective due to surfactant delivery difficulties and deactivation by vascular proteins leaking into the airspace. Here, we demonstrated that surfactant function can be substantially improved (up to 50%) in situ in an in vitro pulmonary airway model using unconventional flows that incorporate a short-term retraction of the air-liquid interface, leading to a net decrease in cellular damage. Computational fluid dynamic simulations provided insights into this method and demonstrated the physicochemical hydrodynamic foundation for the improved surfactant microscale transport and mobility. This study may provide a starting point for developing novel ventilation waveforms to improve surfactant function in edematous airways. |
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Authors:
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Henry W Glindmeyer; Bradford J Smith; Donald P Gaver |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. Date: 2011-10-13 |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 112 ISSN: 1522-1601 ISO Abbreviation: J. Appl. Physiol. Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2011-12-23 Completed Date: 2012-08-21 Revised Date: 2013-02-20 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: United States |
Other Details:
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Languages: eng Pagination: 149-58 Citation Subset: IM |
Affiliation:
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Department of Biomedical Engineering, Tulane University, New Orleans, Louisiana 70118, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cell Death
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drug effects,
physiology Cell Line Cell Line, Tumor Computational Biology / methods Humans Hydrodynamics* Pulmonary Surfactants* / administration & dosage Surface Properties / drug effects |
| Grant Support | |
ID/Acronym/Agency:
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R01-HL-81266/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Pulmonary Surfactants |
| Comments/Corrections | |
Comment In:
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J Appl Physiol. 2012 Feb;112(3):333-4
[PMID:
22134688
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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