Document Detail

[In Process Citation].
MedLine Citation:
PMID:  23876750     Owner:  NLM     Status:  In-Data-Review    
Coagulation assays are prone to pre-analytical problems and results may be influenced by varying clinical and pharmaceutical aspects. Particularly anticoagulants interact with coagulation testing in many ways. Thromboplastin time will be prolonged dose-dependently in patients taking vitamin K antagonists; moreover the new oral anticoagulants have been shown to have variable impact on the results of the thromboplastin time as well as on other coagulation tests, depending on the mechanism of action of these new drugs as well as on the mechanism of the coagulation test. When measuring anti-Xa activity it should be realised that all drugs with anti-Xa activity will influence the result, which means not only heparins but also the new anti-Xa inhibitors. Respective calibration curves are an indispensable condition to provide the clinician with valuable results. On the other hand this implies that the laboratory knows which anticoagulant is given to the patient. This is an example among others that clinical aspects are important to know for proper interpretation of the results of coagulation testing. Other examples are e. g. bleeding disorders, actual bleeding status or thromboembolic events. Several cases are discussed which exemplify possible pitfalls in the interpretation of coagulation testing.
Abstract available from the publisher.
Anita Gähler; Walter A Wuillemin
Publication Detail:
Type:  English Abstract; Journal Article    
Journal Detail:
Title:  Therapeutische Umschau. Revue thérapeutique     Volume:  70     ISSN:  0040-5930     ISO Abbreviation:  Ther Umsch     Publication Date:  2013 Aug 
Date Detail:
Created Date:  2013-07-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0407224     Medline TA:  Ther Umsch     Country:  Switzerland    
Other Details:
Languages:  ger     Pagination:  443-8     Citation Subset:  IM    
Abteilung für Hämatologie und Hämatologisches Zentrallabor, Luzerner Kantonsspital, Luzern.
Vernacular Title:
Pitfalls bei Gerinnungsuntersuchungen.
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