Document Detail

[In Process Citation].
MedLine Citation:
PMID:  23535553     Owner:  NLM     Status:  In-Data-Review    
The promises resulting from the decoding of the human genome have not been fulfilled to the extent as expected. At the same time it is fair to say that the results of recent genetic research have not been useless. In the area of ​​​​familial cancer the clinical benefit of genetic testing for healthy family members is very convincing, where the risk of disease can be reduced substantially through preventive interventions. For example, prophylactic mastectomy and premenopausal ovariectomy can reduce the cancer risk in carriers of BRCA1 and BRCA2 mutations dramatically. In recent years, the research has moved towards the decoding of the genetic causes of sporadic cancers as well. Genome-wide and hypothesis-free association studies have linked different chromosome regions to cancer. By this, new insights into disease mechanisms could be gained, an important requirement for the development of diagnostics and drugs. However, what is missing is the evidence that the associated SNPs (Single Nucleotide Polymorphisms) could be useful for individual risk calculation or for stratification of the population into groups with different preventive or screening needs.
Nicole M Probst-Hensch; Angela Brand
Publication Detail:
Type:  English Abstract; Journal Article    
Journal Detail:
Title:  Therapeutische Umschau. Revue thérapeutique     Volume:  70     ISSN:  0040-5930     ISO Abbreviation:  Ther Umsch     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0407224     Medline TA:  Ther Umsch     Country:  Switzerland    
Other Details:
Languages:  ger     Pagination:  251-6     Citation Subset:  IM    
Swiss Tropical and Public Health Institute, Associated Institute of the University of Basel.
Vernacular Title:
Neue genetische Tests und ihr Nutzen in der Krebsvorsorge.
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