Document Detail

In-parallel attachment of a low-resistance compliant thoracic artificial lung under rest and simulated exercise.
MedLine Citation:
PMID:  22959566     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Previous thoracic artificial lungs (TALs) had blood flow impedance greater than that of the natural lungs, which could cause abnormal pulmonary hemodynamics. New compliant TALs (cTALs), however, have an impedance lower than that of the natural lung.
METHODS: In this study, a cTAL of new design was attached between the pulmonary artery (PA) and the left atrium (LA) in 5 sheep (60.2 ± 1.9 kg). A distal PA band was placed to control the percentage of cardiac output (CO) routed to the cTAL. Rest and exercise conditions were simulated using a continuous dobutamine infusion of 0 and 5 μg/kg/min, respectively. At each dose, a hemodynamic data set was acquired at baseline (no flow to the cTAL), and 60%, 75%, and 90% of CO was shunted to the cTAL.
RESULTS: Device resistance did not vary with blood flow rate, averaging 0.51 ± 0.03 mm Hg/(L/min). Under all conditions, CO was not significantly different from baseline. Pulmonary system impedance increased above baseline only with 5 μg/kg/min of dobutamine and 90% of CO diverted to the cTAL.
CONCLUSIONS: Results indicated minimal changes in pulmonary hemodynamics during PA-LA cTAL attachment for high device flows under rest and exercise conditions.
Rebecca E Schewe; Christopher N Scipione; Kelly L Koch; Keith E Cook
Related Documents :
16024386 - Impact of uv-b exposure on amphibian embryos: linking species physiology and ovipositio...
23177226 - Exercise with incorporated expiratory manoeuvres was as effective as breathing techniqu...
14660216 - Job enlargement and mechanical exposure variability in cyclic assembly work.
7924476 - The effect of pre-exposure to 0.12 ppm of ozone on exercise-induced asthma.
3353456 - Effects of a supervised home exercise program on patients with severe chronic obstructi...
3451796 - Chronotropic and inotropic effects of hyperosmotic solutions on right and left atria is...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-09-07
Journal Detail:
Title:  The Annals of thoracic surgery     Volume:  94     ISSN:  1552-6259     ISO Abbreviation:  Ann. Thorac. Surg.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-26     Completed Date:  2013-01-07     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  15030100R     Medline TA:  Ann Thorac Surg     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1688-94     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2012 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.
Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Artificial Organs*
Lung Compliance*
Physical Conditioning, Animal / physiology*
Prosthesis Implantation / methods
Regional Blood Flow
Rest / physiology*
Vascular Resistance
Grant Support
Comment In:
Ann Thorac Surg. 2012 Nov;94(5):1694   [PMID:  23098945 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Approaching a Paradigm Shift: Endoscopic Ablation of Lone Atrial Fibrillation on the Beating Heart.
Next Document:  Characteristics and Prognostic Value of Lymphatic and Blood Vascular Microinvasion in Lung Cancer.