Document Detail


In-hospital complication rates after stent treatment of 388 symptomatic intracranial stenoses: results from the INTRASTENT multicentric registry.
MedLine Citation:
PMID:  20075358     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND PURPOSE: Stenting is increasingly used as an adjunct to medical therapy in symptomatic intracranial stenoses. High periprocedural adverse event rates are one of the limitations of endovascular treatment. Data from the INTRASTENT multicentric registry should demonstrate in-hospital complications at the current stage of clinical development of the stent procedure. METHODS: Participating centers entered the records of all their consecutive intracranial stent procedures into the database. To determine the clinical outcome in the acute phase, we distinguished transient ischemic attack/nondisabling stroke (modified Rankin Scale <2), disabling stroke, death, and intracranial hemorrhage as clinical complications and analyzed whether they were associated with patient- or stenosis-related risk factors. RESULTS: Data from 372 patients with 388 stenoses proved 4.8% disabling strokes and 2.2% deaths. Transient or minor events were detected in 5.4% of the cases. Hemorrhagic events (3.5%) occurred more frequently after treatment of middle cerebral artery stenoses (P=0.004) and were associated with significantly higher morbidity and mortality rates. Ischemic strokes by compromise of perforating branches were detected mainly in the posterior circulation. However, the overall rate of severe adverse events was not dependent from location, degree, and morphology of the stenosis or from patient's age, gender, vascular risk factors, or type of qualifying event. CONCLUSIONS: The complication rates within the registry are within the limits of previously published data. Severe adverse events were equally distributed between potential risk groups with similar rates but different types of main complications in the anterior and posterior circulation.
Authors:
Wiebke Kurre; Joachim Berkefeld; Friedhelm Brassel; Roland Br?ning; Bernd Eckert; Seniye Kamek; Guenther E Klein; Michael Knauth; Thomas Liebig; Jana Maskova; Dirk Mucha; Tobias Neumann-Haefelin; Sara Pilgram-Pastor; Matthias Sitzer; Michael Sonnberger; Mark Tietke; Johannes Trenkler; Bernd Turowski;
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study     Date:  2010-01-14
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  41     ISSN:  1524-4628     ISO Abbreviation:  Stroke     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-02-23     Completed Date:  2010-04-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  United States    
Other Details:
Languages:  eng     Pagination:  494-8     Citation Subset:  IM    
Affiliation:
Department of Neuroradiology, University of Frankfurt, Schleusenweg 2-16, 60528 Frankfurt, Germany. wiebke.kurre@kgu.de
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MeSH Terms
Descriptor/Qualifier:
Aged
Angioplasty / adverse effects*,  instrumentation,  trends
Constriction, Pathologic / complications,  mortality,  surgery
Female
Follow-Up Studies
Hospitalization / trends*
Humans
Intracranial Arteriosclerosis / complications,  mortality,  surgery*
Male
Middle Aged
Postoperative Complications / diagnosis*,  etiology,  mortality
Prospective Studies
Registries*
Retrospective Studies
Stents / adverse effects*
Treatment Outcome
Investigator
Investigator/Affiliation:
W Kurre / ; S Kamek / ; J Berkefeld / ; M Sitzer / ; T Neumann-Haefelin / ; M Lorenz / ; M Knauth / ; S Pilgram-Pastor / ; R Schramm / ; J H Buhk / ; A K Altona Hamburg / ; B Eckert / ; A Leppien / ; R Br?ning / ; T Fitting / ; J Fiehler / ; O Wittkugel / ; B Turowski / ; D Mucha / ; V P?tz / ; O Jansen / ; M Tietke / ; F Brassel / ; D Meila / ; S Schotes / ; W M?ller-Forell / ; T Liebig / ; F Dorn / ; I Kureck / ; J Klisch / ; V Sychra / ; M Sitzer / ; J Trenkler / ; M Sonnberger / ; H P Haring / ; G E Klein / ; T Mikolits / ; K Niederkorn / ; S Horner / ; W Kueker / ; V Katsaridis / ; J Maskova / ; H Parobkova /

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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