Document Detail


Imputability of heparin in heparin induced thrombocytopenia: a 10 year experience of the Centre Regional de Pharmacovigilance of Reims-Champagne Ardenne.
MedLine Citation:
PMID:  8907624     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The imputability of heparin in heparin induced thrombocytopenia (HIT) was analysed retrospectively in the chart records of 86 cases documented by the Centre Regional de Pharmacovigilance (CRPV) of Reims-Champagne Ardenne over a period of 10 years. Considerable difficulties are encountered in evaluating the degree of imputability. Chronological criteria seem to be determinant in the final imputability score, whereas semiological criteria are particularly difficult to interpret, especially as it is not yet clearly established whether biological tests should be taken into account. The method of assessment requires more precise adaptation to the specific case of HIT and could be improved by redefinition of the criteria in collaboration between pharmacologists and haematologists.
Authors:
P Nguyen; M L Germain; L Sume; H Choisy
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nouvelle revue française d'hématologie     Volume:  37     ISSN:  -     ISO Abbreviation:  Nouv Rev Fr Hematol     Publication Date:  1995  
Date Detail:
Created Date:  1997-03-11     Completed Date:  1997-03-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7909092     Medline TA:  Nouv Rev Fr Hematol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  307-12     Citation Subset:  IM    
Affiliation:
Laboratoire Central d'Hematologie, CHU Robert Debre, France.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Evaluation Studies as Topic
Female
France
Heparin / adverse effects*
Humans
Male
Middle Aged
Pharmacoepidemiology*
Platelet Count / drug effects
Reproducibility of Results
Retrospective Studies
Thrombocytopenia / blood*,  chemically induced*
Chemical
Reg. No./Substance:
9005-49-6/Heparin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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