Document Detail

Impulsivity, attention, memory, and decision-making among adolescent marijuana users.
MedLine Citation:
PMID:  23138434     Owner:  NLM     Status:  MEDLINE    
RATIONALE: Marijuana is a popular drug of abuse among adolescents, and they may be uniquely vulnerable to resulting cognitive and behavioral impairments. Previous studies have found impairments among adolescent marijuana users. However, the majority of this research has examined measures individually rather than multiple domains in a single cohesive analysis. This study used a logistic regression model that combines performance on a range of tasks to identify which measures were most altered among adolescent marijuana users.
OBJECTIVES: The purpose of this research was to determine unique associations between adolescent marijuana use and performances on multiple cognitive and behavioral domains (attention, memory, decision-making, and impulsivity) in 14- to 17-year-olds while simultaneously controlling for performances across the measures to determine which measures most strongly distinguish marijuana users from nonusers.
METHODS: Marijuana-using adolescents (n = 45) and controls (n = 48) were tested. Logistic regression analyses were conducted to test for: (1) differences between marijuana users and nonusers on each measure, (2) associations between marijuana use and each measure after controlling for the other measures, and (3) the degree to which (1) and (2) together elucidated differences among marijuana users and nonusers.
RESULTS: Of all the cognitive and behavioral domains tested, impaired short-term recall memory and consequence sensitivity impulsivity were associated with marijuana use after controlling for performances across all measures.
CONCLUSIONS: This study extends previous findings by identifying cognitive and behavioral impairments most strongly associated with adolescent marijuana users. These specific deficits are potential targets of intervention for this at-risk population.
Donald M Dougherty; Charles W Mathias; Michael A Dawes; R Michael Furr; Nora E Charles; Anthony Liguori; Erin E Shannon; Ashley Acheson
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-11-09
Journal Detail:
Title:  Psychopharmacology     Volume:  226     ISSN:  1432-2072     ISO Abbreviation:  Psychopharmacology (Berl.)     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-25     Completed Date:  2013-09-10     Revised Date:  2014-05-05    
Medline Journal Info:
Nlm Unique ID:  7608025     Medline TA:  Psychopharmacology (Berl)     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  307-19     Citation Subset:  IM    
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MeSH Terms
Anxiety / drug therapy
Attention / drug effects*
Behavior / drug effects
Cannabis / adverse effects*
Cognition / drug effects
Decision Making / drug effects*
Drug-Seeking Behavior / drug effects
Impulsive Behavior / drug therapy*
Memory / drug effects*
Memory, Short-Term / drug effects
Smoking / epidemiology
Substance-Related Disorders / epidemiology
Grant Support
Comment In:
Psychopharmacology (Berl). 2014 Apr;231(8):1433-5
Psychopharmacology (Berl). 2014 Apr;231(8):1433   [PMID:  23779260 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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