Document Detail


Impulsivity as a behavioral measure of withdrawal of orally delivered PCP and nondrug rewards in male and female monkeys.
MedLine Citation:
PMID:  19697013     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Withdrawal of phencyclidine (PCP), ethanol (ETOH), and other drugs reduces operant responding maintained by food. OBJECTIVES: Experiment 1 examined the effects of withdrawing daily short access (2 h) to drug on impulsivity for saccharin (SACC) using a delay discounting task and comparing male and female rhesus monkeys. Experiment 2 examined the effects of withdrawing a nondrug substance (e.g., food or SACC) on impulsivity for PCP. MATERIALS AND METHODS: In experiment 1, either PCP or ETOH was available daily with water for 2 h under a fixed ratio 16 (FR 16) or FR 8 schedule, respectively. In a second component, SACC was available for 45 min under a delay discounting schedule. Next, water was substituted, and drug access was then restored. In experiment 2, PCP was available under a delay discounting schedule during food satiation or restriction or during concurrent SACC vs water access. RESULTS: In experiment 1, withdrawal of 0.5 mg/ml PCP increased impulsivity for SACC, but not SACC intake, in males and females. During 16% ETOH access, impulsivity for SACC was elevated compared to baseline water access, and it returned to baseline levels during ETOH withdrawal. In experiment 2, food restriction resulted in increased PCP intake in males and females and increases in impulsivity for PCP that were greater in males than in females. SACC withdrawal had no effect on impulsivity for PCP or PCP intake. CONCLUSIONS: Withdrawal of PCP and reduced food access increased impulsivity for SACC or PCP, respectively. Impulsivity is a sensitive indicator of drug dependence.
Authors:
Marilyn E Carroll; Jami L Mach; Rachel M La Nasa; Jennifer L Newman
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2009-08-21
Journal Detail:
Title:  Psychopharmacology     Volume:  207     ISSN:  1432-2072     ISO Abbreviation:  Psychopharmacology (Berl.)     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-10-21     Completed Date:  2010-01-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7608025     Medline TA:  Psychopharmacology (Berl)     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  85-98     Citation Subset:  IM    
Affiliation:
Department of Psychiatry, University of Minnesota, MMC 392, Minneapolis, MN 55455, USA. mcarroll@umn.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Central Nervous System Depressants / adverse effects
Dose-Response Relationship, Drug
Ethanol / adverse effects
Female
Food Preferences / drug effects
Hallucinogens / administration & dosage*
Impulsive Behavior / etiology*
Macaca mulatta
Male
Phencyclidine / administration & dosage*
Reinforcement Schedule
Saccharin / administration & dosage
Satiation / drug effects
Self Administration
Sex Factors
Substance Withdrawal Syndrome / complications*,  etiology*
Sweetening Agents / administration & dosage
Time Factors
Grant Support
ID/Acronym/Agency:
K05 DA15267-07/DA/NIDA NIH HHS; R01 DA02486-29/DA/NIDA NIH HHS; T32 DA 07097-29/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
0/Central Nervous System Depressants; 0/Hallucinogens; 0/Sweetening Agents; 64-17-5/Ethanol; 77-10-1/Phencyclidine; 81-07-2/Saccharin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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