Document Detail


Impulsivity and self-control during intertemporal decision making linked to the neural dynamics of reward value representation.
MedLine Citation:
PMID:  23283347     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A characteristic marker of impulsive decision making is the discounting of delayed rewards, demonstrated via choice preferences and choice-related brain activity. However, delay discounting may also arise from how subjective reward value is dynamically represented in the brain when anticipating an upcoming chosen reward. In the current study, brain activity was continuously monitored as human participants freely selected an immediate or delayed primary liquid reward and then waited for the specified delay before consuming it. The ventromedial prefrontal cortex (vmPFC) exhibited a characteristic pattern of activity dynamics during the delay period, as well as modulation during choice, that is consistent with the time-discounted coding of subjective value. The ventral striatum (VS) exhibited a similar activity pattern, but preferentially in impulsive individuals. A contrasting profile of delay-related and choice activation was observed in the anterior PFC (aPFC), but selectively in patient individuals. Functional connectivity analyses indicated that both vmPFC and aPFC exerted modulatory, but opposite, influences on VS activation. These results link behavioral impulsivity and self-control to dynamically evolving neural representations of future reward value, not just during choice, but also during postchoice delay periods.
Authors:
Koji Jimura; Maria S Chushak; Todd S Braver
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of neuroscience : the official journal of the Society for Neuroscience     Volume:  33     ISSN:  1529-2401     ISO Abbreviation:  J. Neurosci.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-03     Completed Date:  2013-03-12     Revised Date:  2013-07-18    
Medline Journal Info:
Nlm Unique ID:  8102140     Medline TA:  J Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  344-57     Citation Subset:  IM    
Affiliation:
Precision and Intelligence Laboratory, Tokyo Institute of Technology, Yokohama 226-8503, Japan. koji.jimura@gmail.com
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Brain / physiology*
Decision Making / physiology*
Female
Humans
Impulsive Behavior / physiopathology*
Internal-External Control
Magnetic Resonance Imaging
Male
Neuropsychological Tests
Reward*
Social Control, Informal*
Grant Support
ID/Acronym/Agency:
R01 MH066078/MH/NIMH NIH HHS; R01 MH66078/MH/NIMH NIH HHS
Comments/Corrections

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