Document Detail

Impulsive action in the 5-choice serial reaction time test in 5-HT(2C) receptor null mutant mice.
MedLine Citation:
PMID:  23192316     Owner:  NLM     Status:  Publisher    
RATIONALE: Depletion of brain serotonin (5-HT) results in impulsive behaviour as measured by increased premature responding in the five-choice serial reaction time (5-CSRT) test. Acute selective blockade of 5-HT(2C) receptors also increases this form of impulsive action, whereas 5-HT(2C) receptor stimulation reduces premature responding. OBJECTIVES: These experiments determined the impact of genetic disruption of 5-HT(2C) receptor function on impulsive responding in the 5-CSRT test. METHODS: Food-restricted 5-HT(2C) receptor null mutant and wild-type (WT) mice were trained on the 5-CSRT test in which subjects detect and correctly respond to brief light stimuli for food reinforcement. Impulsivity is measured as premature responses that occur prior to stimulus presentation. RESULTS: Both lines of mice quickly learned this task, but there were no genotype differences in premature responding or any other aspect of performance. A series of drug challenges were then given. The 5-HT(2C) receptor agonist Ro60-0175 (0.6 mg/kg) reduced premature responding in WT mice but not mutant mice. The 5-HT(2C) receptor antagonist SB242084 increased premature responding in WT mice only. Cocaine increased premature responding at 7.5 mg/kg but not at a higher dose that disrupted overall responding; these effects were observed in both lines of mice. Amphetamine (0.25 and 0.5 mg/kg) did not affect premature responding, but disrupted other aspects of performance in both genotypes. CONCLUSIONS: Genetic deletion of 5-HT(2C) receptor function does not induce an impulsive state or exacerbate that state induced by psychomotor stimulants but does prevent the acute effects of 5-HT(2C) receptor stimulation or blockade on impulsive action.
Paul J Fletcher; Ashlie D Soko; Guy A Higgins
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-29
Journal Detail:
Title:  Psychopharmacology     Volume:  -     ISSN:  1432-2072     ISO Abbreviation:  Psychopharmacology (Berl.)     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7608025     Medline TA:  Psychopharmacology (Berl)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Centre for Addiction and Mental Health, 250 College Street, Toronto, ON, M5T 1R8, Canada,
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