| Improving survival of neonates with isolated congenital diaphragmatic hernia. | |
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MedLine Citation:
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PMID: 15591664 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Despite advances in neonatal care including prenatal diagnosis, conventional ventilation, surfactant, high frequency oscillation, nitric oxide and extracorporeal membrane oxygenation (ECMO) the diagnosis of CDH is reported to carry a high mortality rate. Pulmonary hypoplasia and persistent pulmonary hypertension are major factors that contribute to death. In an effort to improve the survival of these infants a protocolized approach was adopted. In summary, this involves antenatal use of steroids if CDH antenatally diagnosed, sedation and muscle relaxation following tracheal intubation, administration of surfactant, gentle ventilation with permissive hypercapnia, trial of nitric oxide, preoperative ECMO for those infants failing therapy and delayed repair of the CDH. With the use of this protocolized approach the survival of infants with isolated CDH was 96 % for inborn and 81 % for outborn infants. |
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Authors:
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Horacio C Osiovich |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Indian pediatrics Volume: 41 ISSN: 0019-6061 ISO Abbreviation: Indian Pediatr Publication Date: 2004 Nov |
Date Detail:
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Created Date: 2004-12-13 Completed Date: 2006-09-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2985062R Medline TA: Indian Pediatr Country: India |
Other Details:
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Languages: eng Pagination: 1138-42 Citation Subset: IM |
Affiliation:
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Division of Neonatology, British Columbia Children's Hospital, Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada. hosiovich@cw.bc.ca |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Clinical Protocols Extracorporeal Membrane Oxygenation Hernia, Diaphragmatic / congenital, mortality*, therapy* Humans Infant, Newborn Intubation, Intratracheal Prenatal Diagnosis Pulmonary Surfactants / therapeutic use Respiration, Artificial Retrospective Studies Survival Rate Treatment Outcome* |
| Chemical | |
Reg. No./Substance:
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0/Pulmonary Surfactants |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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