Document Detail

Improving the role of intraventricular antimicrobial agents in the management of meningitis.
MedLine Citation:
PMID:  19434796     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: The aim is to review the role of intraventricular administration of antimicrobial agents in the treatment of patients with bacterial and fungal meningitis.
RECENT FINDINGS: This article discusses indications for intraventricular antimicrobial agents, choice of antibiotics, strategies to monitor pharmacokinetics of central nervous system compartments and unanswered issues for this management approach.
SUMMARY: Intraventricular administration of antimicrobials may be necessary in certain difficult- to- eradicate central nervous system infections. There is a significant need for clinical trials and management guidelines in this area.
Wendy C Ziai; John J Lewin
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in neurology     Volume:  22     ISSN:  1473-6551     ISO Abbreviation:  Curr. Opin. Neurol.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-05-11     Completed Date:  2009-07-07     Revised Date:  2013-01-18    
Medline Journal Info:
Nlm Unique ID:  9319162     Medline TA:  Curr Opin Neurol     Country:  England    
Other Details:
Languages:  eng     Pagination:  277-82     Citation Subset:  IM    
Division of Neurosciences Critical Care, Department of Neurology and Anesthesiology-Critical Care Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA.
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MeSH Terms
Anti-Infective Agents* / administration & dosage,  therapeutic use
Cerebral Ventricles / microbiology
Cross Infection / drug therapy
Injections, Intraventricular*
Meningitis, Bacterial / drug therapy*
Microbial Sensitivity Tests
Practice Guidelines as Topic
Reg. No./Substance:
0/Anti-Infective Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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