| Improving quality of life in hypertension management using a fixed-dose combination of olmesartan and amlodipine in primary care. | |
| | |
MedLine Citation:
|
PMID: 20929435 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
OBJECTIVES: To assess quality of life (QoL) in unselected patients in primary care treated with a fixed-dose combination of olmesartan and amlodipine. Research design and methods. Multicenter, noninterventional, noncontrolled observational study in 8241 patients seen by 2187 physicians over 12 - 18 weeks. MAIN OUTCOME MEASURES: Changes in QoL were assessed by using the Short Form 12 (SF-12) questionnaire completed by 5434 patients (65.9%) at baseline and 4924 patients (59.8%) at the follow-up visit. RESULTS: Patients had a mean age of 62.8 ± 11.8 years (48.1% female), mean blood pressure [BP] at baseline was 161.8 ± 16.6/93.6 ± 10.2 mmHg and 74.8% had at least one co-morbid risk factor or condition. All 12 items of the SF-12 improved over the observational period (p < 0.0001) as did the physical (46.8 vs 40.4; p < 0.0001) and mental summary scores (52.4 vs 47.5; p < 0.0001). Correlations of changes in systolic and diastolic BP, pulse pressure and heart rate with scores were significant, although weak (maximum -0.2055 for physical health and changes in systolic blood pressure). CONCLUSIONS: The fixed-dose combination of olmesartan and amlodipine significantly improves QoL in an unselected population of patients in primary-care practice. This might translate into improved patient compliance and improved long-term antihypertensive efficacy. |
| | |
Authors:
|
Peter Bramlage; Wolf-Peter Wolf; Eva-Maria Fronk; Thomas Stuhr; Wolfhard Erdlenbruch; Jürgen Wasem; Reinhard Ketelhut; Roland E Schmieder |
Related Documents
:
|
17612905 - Exceptional early blood pressure control rates: the accomplish trial. 10652905 - Hypertension in india--definition, prevalence and evaluation. 7295465 - Blood pressure, body fluid volumes and glomerular filtration rate during treatment with... 10450715 - Predicting cardiovascular risk using conventional vs ambulatory blood pressure in older... 19965255 - A novel method for the contactless and continuous measurement of arterial blood pressur... 16603685 - Functional alterations after cardiac sodium-calcium exchanger overexpression in heart f... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-10-08 |
Journal Detail:
|
Title: Expert opinion on pharmacotherapy Volume: 11 ISSN: 1744-7666 ISO Abbreviation: Expert Opin Pharmacother Publication Date: 2010 Dec |
Date Detail:
|
Created Date: 2010-11-05 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100897346 Medline TA: Expert Opin Pharmacother Country: England |
Other Details:
|
Languages: eng Pagination: 2779-90 Citation Subset: IM |
Affiliation:
|
Institute for Cardiovascular Pharmacology and Epidemiology, Mahlow, Germany. peter.bramlage@ikpe.de |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Epirubicin-encapsulated long-circulating thermosensitive liposome improves pharmacokinetics and anti...
Next Document: Concerns and hopes for stem cell therapy in cardiology: focus on endothelial progenitor cells.