Document Detail

Improving the precision of biological age determinations. Part 1: A new approach to calculating biological age.
MedLine Citation:
PMID:  2684676     Owner:  NLM     Status:  MEDLINE    
In calculating biological age, almost all prior studies used multiple regression of chronological age on scores of biomarkers of aging. Multiple regression is invalid for this purpose for three, and in some circumstances four, reasons. These are: a) weighting of the contribution of each biomarker's scores according to strength of association with chronological age; b) regression of calculated ages to sample mean age and the inadequacy of proposed corrections; c) frequent occurrence of regression coefficients whose sign equates poorer adult performance on a test to younger biological ages; and d) multicollinearity when lung function scores and height are on the same side of the regression equation. An alternative method for calculating biological age is outlined. Regression to sample mean age and its solution are illustrated on data for highest audible pitch, one of 12 biomarkers measured in a study of 2462 office workers. Prior published studies employing multiple regression to calculate biological age appear to have been in error.
R Hochschild
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Experimental gerontology     Volume:  24     ISSN:  0531-5565     ISO Abbreviation:  Exp. Gerontol.     Publication Date:  1989  
Date Detail:
Created Date:  1989-12-29     Completed Date:  1989-12-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0047061     Medline TA:  Exp Gerontol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  289-300     Citation Subset:  IM    
Hoch Company, Corona del Mar, California 92625.
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MeSH Terms
Aging / physiology*
Middle Aged

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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