Document Detail


Improving the power of diagnostics in the era of targeted therapy and personalized healthcare.
MedLine Citation:
PMID:  20205056     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The field of diagnostics has unprecedented opportunities to contribute to the practice of medicine in the era of targeted therapy and personalized healthcare. Rather than simply providing information regarding the presence and classification of disease, innovative molecular diagnostic tests will directly inform patient-management decisions, such as which targeted therapies to prescribe or whether a patient should be treated more aggressively. However, in order for diagnostics to deliver this high level of medical value, several challenges ranging from technical, pre-analytical, developmental, regulatory, reimbursement and quality perspectives need to be overcome. This review focuses on recent developments in each of these areas that are expected to improve the power and impact of diagnostics.
Authors:
Eric E Walk
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in drug discovery & development     Volume:  13     ISSN:  2040-3437     ISO Abbreviation:  Curr Opin Drug Discov Devel     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-05     Completed Date:  2010-06-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100887519     Medline TA:  Curr Opin Drug Discov Devel     Country:  England    
Other Details:
Languages:  eng     Pagination:  226-34     Citation Subset:  IM    
Affiliation:
Ventana Medical Systems Inc, Tucson, AZ 85755, USA. eric.walk@ventana.roche.com
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MeSH Terms
Descriptor/Qualifier:
Drug Design
Humans
Molecular Diagnostic Techniques / methods*,  trends*
Mutation / genetics
Neoplasms / diagnosis,  genetics,  therapy
Pathology, Molecular
Personal Health Services* / economics
Pharmacogenetics / trends*
Reimbursement Mechanisms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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