Document Detail

Improving portable inhalation therapy through real-time assessment of patient pulmonary state.
MedLine Citation:
PMID:  9731411     Owner:  NLM     Status:  MEDLINE    
Metered-dose inhalation therapy is the method of choice for a number of respiratory conditions including asthma and bronchitis. Correct use of the metered-dose inhaler (MDI) has been the subject of much research. Devices have been developed to assist with training in their proper use and to enhance the effectiveness of MDI therapy. However, all lack patient pulmonary state assessment. We have approached the development of an improved portable MDI device by focusing on the total system elements that contribute to a smart inhalation therapy device. Components of such a system should include assessment of the patient's therapeutic state, tracking of drug usage, and also include physician-modified alarm thresholds. Therapeutic state is best assessed with end-expiratory CO2 measurements augmented by inspiratory and expiratory flow efforts. Drug usage monitoring needs to include the time history of drug administration. Physician-modified alarms should allow configuration of the smart inhaler to account for patient condition so that appropriate alarm limits can be established; for example, raising the CO2 alarm threshold for patients with chronic lung disease.
N A Berk; T C Crompton; P M Jansson; J L Schmalzel
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biomedical sciences instrumentation     Volume:  33     ISSN:  0067-8856     ISO Abbreviation:  Biomed Sci Instrum     Publication Date:  1997  
Date Detail:
Created Date:  1998-09-24     Completed Date:  1998-09-24     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0140524     Medline TA:  Biomed Sci Instrum     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  503-8     Citation Subset:  IM    
School of Engineering, Rowan College, Glassboro, NJ 08028, USA.
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MeSH Terms
Administration, Inhalation
Asthma / drug therapy*,  physiopathology
Bronchodilator Agents / administration & dosage
Carbon Dioxide / analysis
Equipment Design
Nebulizers and Vaporizers*
Patient Compliance
Reg. No./Substance:
0/Bronchodilator Agents; 124-38-9/Carbon Dioxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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