Document Detail

Improving photodynamic inactivation of bacteria in dentistry: Highly effective and fast killing of oral key pathogens with novel tooth-colored type-II photosensitizers.
MedLine Citation:
PMID:  24884918     Owner:  NLM     Status:  Publisher    
Increasing antibiotic resistances in microorganisms involve serious problems in public health. This demands alternative approaches for killing pathogens to supplement standard treatment methods. Photodynamic inactivation of bacteria (PIB) uses light activated photosensitizers (PS) to generate reactive oxygen species immediately upon illumination, inducing lethal phototoxicity. Positively charged phenalen-1-one derivatives are a new generation of photosensitizers for light-mediated killing of pathogens with outstanding singlet oxygen quantum yield ΦΔ of > 97%. Upon irradiation with a standard photopolymerizer light (bluephase® C8, 1260 ± 50 mW/cm2) the photosensitizers showed high activity against the oral key pathogens Enterococcus faecalis, Actinomyces naeslundii, Streptococcus mutans and Aggregatibacter actinomycetemcomitans. At a concentration of 10 µM a maximum efficacy of more than 6 log10 steps (≥ 99.9999 %) of bacteria killing is reached in less than one minute (light dose 50 J/cm2) after one single treatment. The pyridinium substituent as positively charged moiety is especially advantageous for antimicrobial action.
Andreas Spaeth; Christoph Leibl; Fabian Cieplik; Karin Lehner; Johannes Regensburger; Karl-Anton Hiller; Wolfgang Bäumler; Gottfried Schmalz; Tim Maisch
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-6-2
Journal Detail:
Title:  Journal of medicinal chemistry     Volume:  -     ISSN:  1520-4804     ISO Abbreviation:  J. Med. Chem.     Publication Date:  2014 Jun 
Date Detail:
Created Date:  2014-6-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9716531     Medline TA:  J Med Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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