| Improving patient-controlled analgesia: adding droperidol to morphine sulfate to reduce nausea and vomiting and potentiate analgesia. | |
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MedLine Citation:
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PMID: 7616978 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Opioid-related side effects, including nausea and vomiting, are common in patients using morphine in patient-controlled analgesia for postoperative pain relief. The purpose of this study was to determine if the addition of droperidol to a morphine sulfate delivery system could decrease the incidences of nausea and vomiting without increasing droperidol-related side effects. Forty ASA 1 and 2 patients scheduled to undergo peripheral orthopedic surgery were randomized to receive either morphine sulfate (2 mg/mL), or morphine sulfate (1.9 mg/mL) plus droperidol (0.125 mg/mL) for postoperative self-controlled analgesia. Visual analogue scores for pain, nausea, and sedation were obtained from each patient immediately after surgery and each morning and evening until patient-controlled analgesia was discontinued approximately 48 hours later. Total patient-controlled use of morphine sulfate was recorded at each visual analogue rating. The patients who used morphine sulfate plus droperidol had significantly less nausea and vomiting and used significantly less morphine. No patient experienced droperidol-related side effects. We conclude that the routine addition of droperidol to morphine sulfate in self-controlled analgesia improves the comfort of patients following peripheral orthopedic surgery. |
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Authors:
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G M Freedman; J M Kreitzer; S S Reuben; J B Eisenkraft |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: The Mount Sinai journal of medicine, New York Volume: 62 ISSN: 0027-2507 ISO Abbreviation: Mt. Sinai J. Med. Publication Date: 1995 May |
Date Detail:
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Created Date: 1995-08-23 Completed Date: 1995-08-23 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0241032 Medline TA: Mt Sinai J Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 221-5 Citation Subset: IM |
Affiliation:
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Department of Anesthesiology, Mount Sinai School of Medicine (CUNY), New York 10029, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analgesia, Patient-Controlled* Droperidol / administration & dosage*, pharmacology Drug Combinations Drug Synergism Female Humans Male Middle Aged Morphine / administration & dosage, adverse effects* Nausea / etiology, prevention & control* Pain, Postoperative / drug therapy* Self Administration |
| Chemical | |
Reg. No./Substance:
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0/Drug Combinations; 548-73-2/Droperidol; 57-27-2/Morphine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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