| Improving oxygenator performance using computational simulation and flow field-based parameters. | |
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MedLine Citation:
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PMID: 21092036 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Current goals in the development of oxygenators are to reduce extrinsic surface contact area, thrombus formation, hemolysis, and priming volume. To achieve these goals and provide a favorable concentration gradient for the gas exchange throughout the fiber bundle, this study attempts to find an optimized inlet and outlet port geometry to guide the flow of a hexagonal-shaped oxygenator currently under development. Parameters derived from numerical flow simulations allowed an automated quantitative evaluation of geometry changes of flow distribution plates. This led to a practical assessment of the quality of the flow. The results were validated qualitatively by comparison to flow visualization results. Two parameters were investigated, the first based on the velocity distribution and the second calculated from the residence time of massless particles representing erythrocytes. Both approaches showed significant potential to improve the flow pattern in the fiber bundle, based on one of the parameters of up to 66%. Computational fluid dynamics combined with a parameterization proved to be a powerful tool to quickly improve oxygenator designs. |
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Authors:
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Roland Graefe; Ralf Borchardt; Jutta Arens; Peter Schlanstein; Thomas Schmitz-Rode; Ulrich Steinseifer |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Artificial organs Volume: 34 ISSN: 1525-1594 ISO Abbreviation: Artif Organs Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7802778 Medline TA: Artif Organs Country: United States |
Other Details:
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Languages: eng Pagination: 930-6 Citation Subset: IM |
Copyright Information:
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© 2010, Copyright RWTH Aachen University. Artificial Organs © 2010, International Center for Artificial Organs and Transplantation and Wiley Periodicals, Inc. |
Affiliation:
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Applied Medical Engineering, Helmholtz Institute, RWTH Aachen University, Aachen, Germany. graefe@hia.rwth-aachen.de |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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