Document Detail


Improving outcomes after cardiac arrest using NO inhalation.
MedLine Citation:
PMID:  23291033     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Despite advances in cardiopulmonary resuscitation (CPR) methods including therapeutic hypothermia (TH), long-term neurological outcomes and survival after sudden cardiac arrest (CA) remains to be dismal. While nitric oxide (NO) prevents organ injury induced by ischemia and reperfusion (I/R), systemic vasodilation induced by intravenous NO-donor compounds typically precludes its use in post-CA patients in whom blood pressure is often low and unstable. Although developed as a selective pulmonary vasodilator, inhaled NO has systemic benefits in a variety of pre-clinical and clinical studies without causing potentially harmful systemic vasodilation. Breathing NO after CPR may prevent post-CA brain injury and improve long-term outcomes after CA and CPR.
Authors:
Fumito Ichinose
Related Documents :
2369233 - Reversibility of pulmonary artery hypertension in aortic stenosis after aortic valve re...
10826403 - Effect of amlodipine on hemodynamic and endocrine responses to mental stress.
2795633 - A microcomputer-based system for the accurate continuous measurement of ventilation and...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2013-01-03
Journal Detail:
Title:  Trends in cardiovascular medicine     Volume:  23     ISSN:  1873-2615     ISO Abbreviation:  Trends Cardiovasc. Med.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-02-06     Completed Date:  2013-07-30     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  9108337     Medline TA:  Trends Cardiovasc Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  52-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Elsevier Inc. All rights reserved.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Administration, Inhalation
Animals
Cardiopulmonary Resuscitation*
Heart Arrest / therapy*
Mice
Nitric Oxide / administration & dosage*
Treatment Outcome
Grant Support
ID/Acronym/Agency:
HL101930/HL/NHLBI NIH HHS; HL110378/HL/NHLBI NIH HHS; R01 HL101930/HL/NHLBI NIH HHS; R01 HL110378/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
31C4KY9ESH/Nitric Oxide
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Analysis of selection bias in the pilot study of a longitudinal study on aging in Spain.
Next Document:  Assessment of Cryptosporidium parvum infection in immunocompetent and immunocompromised mice and its...