Document Detail


Improving the outcome of neonatal meningitis.
MedLine Citation:
PMID:  19333122     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE OF REVIEW: Neonatal meningitis is an important cause of mortality and morbidity worldwide, and although mortality has declined in developed countries over the last two decades, improvement in morbidity has been less evident. This review focuses on recent advances in the management of neonatal meningitis and its implications for improved outcomes.
RECENT FINDINGS: Recent surveillance studies of neonatal meningitis have provided important information regarding the pathogens causing meningitis, their antibiotic-susceptibility profiles and their outcomes. Data supporting the importance of early recognition of the signs of neonatal meningitis, the early diagnosis of the causative pathogen, early and aggressive fluid therapy and supportive care and on the effect of adjunctive therapies on outcome measures are all largely theoretical or derived from paediatric and adult sepsis studies.
SUMMARY: There is likely to be considerable scope for improving the outcome from neonatal meningitis but more studies are required to define key interventions and to demonstrate their effectiveness.
Authors:
Eva P Galiza; Paul T Heath
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in infectious diseases     Volume:  22     ISSN:  1473-6527     ISO Abbreviation:  Curr. Opin. Infect. Dis.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-04-28     Completed Date:  2009-05-14     Revised Date:  2012-01-31    
Medline Journal Info:
Nlm Unique ID:  8809878     Medline TA:  Curr Opin Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  229-34     Citation Subset:  IM    
Affiliation:
Vaccine Institute, London, UK. egaliza@sgul.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Case Management*
Humans
Infant Welfare*
Infant, Newborn
Meningitis, Bacterial / mortality,  therapy*
Treatment Outcome

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