| Improving neurological outcomes post-cardiac arrest in a rat model: immediate hypothermia and quantitative EEG monitoring. | |
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MedLine Citation:
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PMID: 17936492 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: Therapeutic hypothermia (TH) after cardiac arrest (CA) improves outcomes in a fraction of patients. To enhance the administration of TH, we studied brain electrophysiological monitoring in determining the benefit of early initiation of TH compared to conventional administration in a rat model. METHODS: Using an asphyxial CA model, we compared the benefit of immediate hypothermia (IH, T=33 degrees C, immediately post-resuscitation, maintained 6h) to conventional hypothermia (CH, T=33 degrees C, starting 1h post-resuscitation, maintained 12h) via surface cooling. We tracked quantitative EEG using relative entropy (qEEG) with outcome verification by serial Neurological Deficit Score (NDS) and quantitative brain histopathological damage scoring (HDS). Thirty-two rats were divided into 4 groups based on CH/IH and 7/9-min duration of asphyxial CA. Four sham rats were included for evaluation of the effect of hypothermia on qEEG. RESULTS: The 72-h NDS of the IH group was significantly better than the CH group for both 7-min (74/63; median, IH/CH, p<0.001) and 9-min (54/47, p=0.022) groups. qEEG showed greater recovery with IH (p<0.001) and significantly less neuronal cortical injury by HDS (IH: 18.9+/-2.5% versus CH: 33.2+/-4.4%, p=0.006). The 1-h post-resuscitation qEEG correlated well with 72-h NDS (p<0.05) and 72-h behavioral subgroup of NDS (p<0.01). No differences in qEEG were noted in the sham group. CONCLUSIONS: Immediate but shorter hypothermia compared to CH leads to better functional outcome in rats after 7- and 9-min CA. The beneficial effect of IH was readily detected by neuro-electrophysiological monitoring and histological changes supported the value of this observation. |
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Authors:
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Xiaofeng Jia; Matthew A Koenig; Hyun-Chool Shin; Gehua Zhen; Carlos A Pardo; Daniel F Hanley; Nitish V Thakor; Romergryko G Geocadin |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2007-10-23 |
Journal Detail:
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Title: Resuscitation Volume: 76 ISSN: 0300-9572 ISO Abbreviation: Resuscitation Publication Date: 2008 Mar |
Date Detail:
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Created Date: 2008-02-11 Completed Date: 2008-06-03 Revised Date: 2012-01-06 |
Medline Journal Info:
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Nlm Unique ID: 0332173 Medline TA: Resuscitation Country: Ireland |
Other Details:
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Languages: eng Pagination: 431-42 Citation Subset: IM |
Affiliation:
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Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. xjia1@jhmi.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain Ischemia / pathology*, prevention & control Cardiopulmonary Resuscitation Electroencephalography* Heart Arrest, Induced* Hypothermia, Induced* Male Models, Animal Neurons / pathology Random Allocation Rats Rats, Wistar Recovery of Function Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL071568/HL/NHLBI NIH HHS; R01 HL071568-04/HL/NHLBI NIH HHS; R01 HL071568-09/HL/NHLBI NIH HHS; R21 NS054146/NS/NINDS NIH HHS; R21 NS054146-01/NS/NINDS NIH HHS |
| Comments/Corrections | |
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