Document Detail

Improving muscle mass and function in cachexia: non-drug approaches.
MedLine Citation:
PMID:  21934503     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: Therapeutic exercise may help maintain or slow down the rate of decline in muscle mass and physical function that occurs with cachexia. This review considers recent evidence in relation to patients with cachexia as regards the rationale for the use of exercise, the challenges in its clinical application and future developments.
RECENT FINDINGS: Exercise may attenuate the effects of cachexia by modulating muscle metabolism, insulin sensitivity and levels of inflammation. Studies targeting cachectic patients have demonstrated that even in advanced disease peripheral muscle has the capacity to respond to exercise training. Nonetheless, there are challenges in implementing the use of exercise, particularly once cachexia is established in which tolerance to even low levels of exercise is poor. Strategies to make exercise a more accessible therapy are required and could include offering exercise earlier on in the course of the disease, at lower intensities and in various forms, including more novel approaches.
SUMMARY: The use of therapeutic exercise has a sound rationale, even in patients with advanced disease and cachexia. Because of practical issues with its application, further study is required to examine if benefits achieved in small studies can be translated to a wider clinical population.
Matthew Maddocks; Andrew J Murton; Andrew Wilcock
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in supportive and palliative care     Volume:  5     ISSN:  1751-4266     ISO Abbreviation:  Curr Opin Support Palliat Care     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-11-02     Completed Date:  2012-03-05     Revised Date:  2014-03-14    
Medline Journal Info:
Nlm Unique ID:  101297402     Medline TA:  Curr Opin Support Palliat Care     Country:  United States    
Other Details:
Languages:  eng     Pagination:  361-4     Citation Subset:  IM    
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MeSH Terms
Cachexia / metabolism,  prevention & control,  therapy*
Exercise Therapy / methods*
Inflammation / metabolism
Insulin Resistance
Muscle Contraction / physiology
Muscle, Skeletal / metabolism*
Neoplasms / complications*
Grant Support
PDF-2011-04-048//Department of Health

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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