| Improving the magnetic resonance imaging contrast and detection methods with engineered magnetic nanoparticles. | |
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MedLine Citation:
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PMID: 22272222 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Engineering and functionalizing magnetic nanoparticles have been an area of the extensive research and development in the biomedical and nanomedicine fields. Because their biocompatibility and toxicity are well investigated and better understood, magnetic nanoparticles, especially iron oxide nanoparticles, are better suited materials as contrast agents for magnetic resonance imaging (MRI) and for image-directed delivery of therapeutics. Given tunable magnetic properties and various surface chemistries from the coating materials, most applications of engineered magnetic nanoparticles take advantages of their superb MRI contrast enhancing capability as well as surface functionalities. It has been found that MRI contrast enhancement by magnetic nanoparticles is highly dependent on the composition, size and surface properties as well as the degree of aggregation of the nanoparticles. Therefore, understanding the relationships between these intrinsic parameters and the relaxivities that contribute to MRI contrast can lead to establishing essential guidance that may direct the design of engineered magnetic nanoparticles for theranostics applications. On the other hand, new contrast mechanism and imaging strategy can be developed based on the novel properties of engineered magnetic nanoparticles. This review will focus on discussing the recent findings on some chemical and physical properties of engineered magnetic nanoparticles affecting the relaxivities as well as the impact on MRI contrast. Furthermore, MRI methods for imaging magnetic nanoparticles including several newly developed MRI approaches aiming at improving the detection and quantification of the engineered magnetic nanoparticles are described. |
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Authors:
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Jing Huang; Xiaodong Zhong; Liya Wang; Lily Yang; Hui Mao |
Publication Detail:
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Type: Journal Article Date: 2012-01-10 |
Journal Detail:
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Title: Theranostics Volume: 2 ISSN: 1838-7640 ISO Abbreviation: Theranostics Publication Date: 2012 |
Date Detail:
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Created Date: 2012-01-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101552395 Medline TA: Theranostics Country: Australia |
Other Details:
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Languages: eng Pagination: 86-102 Citation Subset: - |
Affiliation:
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1. Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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