| Improving insulin resistance in obese youth: Choose your measures wisely. | |
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MedLine Citation:
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PMID: 21070095 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Abstract Objective. The purpose of this investigation was to compare the homeostasis model assessment of insulin resistance (HOMA-IR) to more direct measures of insulin action before and after lifestyle interventions in obese Latino youth. Study design. Eleven obese Latino boys (age 15.1 ± 1.6 years, body mass index (BMI) percentile 97.3 ± 3.5%) and twenty obese Latina girls (age 14.7 ± 1.8 years, BMI percentile 96.6 ± 3.6%) participated in two distinct lifestyle interventions. Boys participated in a 16-week exercise intervention and girls participated in a 12-week nutrition education program. Insulin sensitivity was determined by the frequently sampled intravenous glucose tolerance test (FSIVGTT) in boys and by a 3-hour oral glucose tolerance test with multiple sampling calculations for the whole-body insulin sensitivity index (WBISI) in girls. HOMA-IR was measured for both groups. Results. HOMA-IR was correlated at baseline to the FSIVGTT (r = -0.57, p = 0.07) and the WBISI (r = -0.78, p<0.01) and at follow-up (FSIVGTT: r = -0.81, p<0.003; WBISI: r = -0.71, p = 0.001). Post-intervention, insulin sensitivity increased 45% in the boys and 34% in the girls; however, these improvements were not reflected by significant changes in HOMA-IR. Conclusions. Improvements in insulin sensitivity following an intervention measured either by the FSIVGTT or an OGTT were not detected by HOMA-IR. Researchers and clinicians should exercise caution in relying on fasting indices, such as HOMA-IR, to determine the impact of lifestyle interventions on insulin sensitivity in overweight youth. |
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Authors:
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Gabriel Q Shaibi; Jaimie N Davis; Marc J Weigensberg; Michael I Goran |
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Publication Detail:
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Type: Journal Article Date: 2010-11-11 |
Journal Detail:
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Title: International journal of pediatric obesity : IJPO : an official journal of the International Association for the Study of Obesity Volume: 6 ISSN: 1747-7174 ISO Abbreviation: Int J Pediatr Obes Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-07-01 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101256330 Medline TA: Int J Pediatr Obes Country: England |
Other Details:
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Languages: eng Pagination: e290-6 Citation Subset: IM |
Affiliation:
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Department of Kinesiology, Center for Metabolic Biology, and College of Nursing & Health Innovation, Arizona State University , Phoenix, AZ. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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