| Improving the induction characteristics of methohexitone. A study of the effect of adding thiopentone to methohexitone. | |
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MedLine Citation:
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PMID: 8179146 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A double-blind, randomised, controlled study was undertaken to investigate the effects on injection pain and excitatory phenomena of adding thiopentone to methohexitone. One hundred and twenty unpremedicated, day-case patients received one of four induction regimens: unmodified 1% methohexitone, or a mixture of 2.5% thiopentone and 1% methohexitone in ratios of 1:1, 1:3 or 1:9 by volume. The addition of one part of thiopentone to three parts of methohexitone produced a mixture which significantly reduced the occurrence of pain and discomfort compared with methohexitone alone from 67% to 13% (p < 0.01) and reduced the occurrence of excitatory effects from 50% to 13% (p < 0.01). |
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Authors:
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J H Raphael; M D Bexton |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Anaesthesia Volume: 49 ISSN: 0003-2409 ISO Abbreviation: Anaesthesia Publication Date: 1994 Apr |
Date Detail:
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Created Date: 1994-06-06 Completed Date: 1994-06-06 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0370524 Medline TA: Anaesthesia Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 338-40 Citation Subset: AIM; IM |
Affiliation:
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Department of Anaesthetics, Pilgrim Hospital, Boston, Lincolnshire. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Anesthesia, Intravenous* / adverse effects Female Hiccup / prevention & control Humans Intraoperative Complications / prevention & control Laryngismus / prevention & control Male Methohexital* Middle Aged Muscle Contraction / drug effects Pain / prevention & control Thiopental* |
| Chemical | |
Reg. No./Substance:
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18652-93-2/Methohexital; 76-75-5/Thiopental |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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