Document Detail

Improving in-vitro tests for the diagnosis of food hypersensitivity.
MedLine Citation:
PMID:  12045424     Owner:  NLM     Status:  MEDLINE    
Food hypersensitivity reactions affect up to 8% of children under 3 years of age and approximately 2.5% of the general United States population. Food allergic disorders may be subdivided into either IgE-mediated or cell-mediated reactions. The diagnostic 'gold standard' of 'symptomatic' food allergies remains the blinded oral food challenge because of the poor specificity of patient histories, skin testing and standard radioallergosorbent tests, and the outcomes of elimination diets. Little progress has been made in the development of in-vitro tests for the diagnosis of cell-mediated food hypersensitivities. However, new developments in in-vitro technologies have improved the capabilities of these tests to diagnose IgE-mediated reactivity and perhaps predict the development of future 'tolerance', i.e. 'outgrowing' the allergy.
Hugh A Sampson
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in allergy and clinical immunology     Volume:  2     ISSN:  1528-4050     ISO Abbreviation:  Curr Opin Allergy Clin Immunol     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-06-04     Completed Date:  2002-10-18     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  100936359     Medline TA:  Curr Opin Allergy Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  257-61     Citation Subset:  IM    
Division of Pediatric Allergy and Immunology, Jaffe Food Allergy Institute, Mount Sinai School of Medicine, New York, New York 10538, USA.
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MeSH Terms
Allergens / adverse effects,  immunology
Antibody Specificity / immunology
Arachis hypogaea / adverse effects,  immunology
Diagnostic Tests, Routine / standards*
Egg Proteins, Dietary / adverse effects,  immunology
Food Hypersensitivity / diagnosis*,  immunology
Immunoglobulin E / diagnostic use,  immunology
Immunoglobulin G / diagnostic use,  immunology
Milk Proteins / adverse effects,  immunology
United States / epidemiology
Reg. No./Substance:
0/Allergens; 0/Egg Proteins, Dietary; 0/Immunoglobulin G; 0/Milk Proteins; 37341-29-0/Immunoglobulin E

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