| Improving fMRI sensitivity by normalization of basal physiologic state. | |
| | |
MedLine Citation:
|
PMID: 19585589 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The power of fMRI in assessing neural activities is hampered by inter-subject variations in basal physiologic parameters, which may not be related to neural activation but has a modulatory effect on fMRI signals. Therefore, normalization of fMRI signals with these parameters is useful in reducing variations and improving sensitivity of this important technique. Recently, we have shown that basal venous oxygenation is a significant modulator of fMRI signals and individuals with higher venous oxygenation tend to have lower fMRI signals. In this study, we aim to test the utility of venous oxygenation normalization in distinguishing subject groups. A "model" condition was used in which two visual stimuli with different flashing frequencies were used to stimulate two subject groups, respectively, thereby simulating the situation of control and patient groups. It was found that visual-evoked BOLD signal is significantly correlated with baseline venous T2 (P = 0.0003) and inclusion of physiologic modulator in the regression analysis can substantially reduce P values of group-level statistical tests. When applied to voxel-wise analysis, the normalization process can allow the detection of more significant voxels. The utility of other basal parameters, including blood pressure, heart rate, arterial oxygenation, and end-tidal CO(2), in BOLD normalization was also assessed and it was found that the improvement was less significant. Time-to-peak of the BOLD responses was also studied and it was found that subjects with higher basal venous oxygenation tend to slower BOLD responses. |
| | |
Authors:
|
Hanzhang Lu; Uma S Yezhuvath; Guanghua Xiao |
Related Documents
:
|
15246329 - Comparison of the college alumnus questionnaire physical activity index with objective ... 14682979 - Synchronization between main rhythmic processes in the human cardiovascular system. 11103859 - Differences in beat-to-beat variability of the qt interval between day and night. 16167189 - Review of four studies on the use of physiological reaction as a measure of presence in... 6641839 - Exploring the functional significance of physiological tremor: a biospectroscopic appro... 11897189 - Cardiac rhythms in developing emu hatchlings. 10668669 - On the assessment of stability and patterning of speech movements. 21246709 - Morphological integration and ontogenetic niche shift: a study of crested newt limbs. 1186159 - Most comfortable loudness for pure tones and speech in the presence of masking noise. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Human brain mapping Volume: 31 ISSN: 1097-0193 ISO Abbreviation: Hum Brain Mapp Publication Date: 2010 Jan |
Date Detail:
|
Created Date: 2009-12-22 Completed Date: 2010-03-05 Revised Date: 2011-07-19 |
Medline Journal Info:
|
Nlm Unique ID: 9419065 Medline TA: Hum Brain Mapp Country: United States |
Other Details:
|
Languages: eng Pagination: 80-7 Citation Subset: IM |
Copyright Information:
|
2009 Wiley-Liss, Inc. |
Affiliation:
|
Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, 75390, USA. hanzhang.lu@utsouthwestern.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Artifacts Brain / physiology* Brain Mapping / methods* Cardiovascular Physiological Phenomena* Cerebrovascular Circulation / physiology Evoked Potentials, Visual / physiology Female Humans Image Processing, Computer-Assisted / methods Magnetic Resonance Imaging / methods* Male Oxygen Consumption / physiology Photic Stimulation Reference Values Sensitivity and Specificity Signal Processing, Computer-Assisted Veins / physiology Young Adult |
| Grant Support | |
ID/Acronym/Agency:
|
R01 MH084021/MH/NIMH NIH HHS; R01 MH084021-02/MH/NIMH NIH HHS; R01 MH084021-04/MH/NIMH NIH HHS; R21 EB007821/EB/NIBIB NIH HHS; R21 NS054916/NS/NINDS NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Neural representation of anxiety and personality during exposure to anxiety-provoking and neutral sc...
Next Document: Tuning-in to the beat: Aesthetic appreciation of musical rhythms correlates with a premotor activity...