| Improving dynamic susceptibility contrast MRI measurement of quantitative cerebral blood flow using corrections for partial volume and nonlinear contrast relaxivity: A xenon computed tomographic comparative study. | |
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MedLine Citation:
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PMID: 19787719 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To test whether dynamic susceptibility contrast MRI-based CBF measurements are improved with arterial input function (AIF) partial volume (PV) and nonlinear contrast relaxivity correction, using a gold-standard CBF method, xenon computed tomography (xeCT). MATERIALS AND METHODS: Eighteen patients with cerebrovascular disease underwent xeCT and MRI within 36 h. PV was measured as the ratio of the area under the AIF and the venous output function (VOF) concentration curves. A correction was applied to account for the nonlinear relaxivity of bulk blood (BB). Mean CBF was measured with both techniques and regression analyses both within and between patients were performed. RESULTS: Mean xeCT CBF was 43.3 +/- 13.7 mL/100g/min (mean +/- SD). BB correction decreased CBF by a factor of 4.7 +/- 0.4, but did not affect precision. The least-biased CBF measurement was with BB but without PV correction (45.8 +/- 17.2 mL/100 g/min, coefficient of variation [COV] = 32%). Precision improved with PV correction, although absolute CBF was mildly underestimated (34.3 +/- 10.8 mL/100 g/min, COV = 27%). Between patients correlation was moderate even with both corrections (R = 0.53). CONCLUSION: Corrections for AIF PV and nonlinear BB relaxivity improve bolus MRI-based CBF maps. However, there remain challenges given the moderate between-patient correlation, which limit diagnostic confidence of such measurements in individual patients. |
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Authors:
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Greg Zaharchuk; Roland Bammer; Matus Straka; Rexford D Newbould; Jarrett Rosenberg; Jean-Marc Olivot; Michael Mlynash; Maarten G Lansberg; Neil E Schwartz; Michael M Marks; Gregory W Albers; Michael E Moseley |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of magnetic resonance imaging : JMRI Volume: 30 ISSN: 1053-1807 ISO Abbreviation: J Magn Reson Imaging Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-10-05 Completed Date: 2009-12-17 Revised Date: 2011-08-04 |
Medline Journal Info:
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Nlm Unique ID: 9105850 Medline TA: J Magn Reson Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 743-52 Citation Subset: IM |
Copyright Information:
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(c) 2009 Wiley-Liss, Inc. |
Affiliation:
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Department of Radiology, Stanford University, Stanford, California, USA. gregz@stanford.edu |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Cerebrovascular Circulation* Cerebrovascular Disorders / diagnosis*, radiography Contrast Media Female Gadolinium DTPA / diagnostic use Humans Magnetic Resonance Angiography / methods* Male Middle Aged Tomography, X-Ray Computed / methods* Xenon / diagnostic use |
| Grant Support | |
ID/Acronym/Agency:
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1R21EB006860/EB/NIBIB NIH HHS; 2R01EB002711/EB/NIBIB NIH HHS; K23 NS051372-04S1/NS/NINDS NIH HHS; K23NS051372/NS/NINDS NIH HHS; P41 RR009784-09/RR/NCRR NIH HHS; P41RR09784/RR/NCRR NIH HHS; R01 EB002711-06/EB/NIBIB NIH HHS; R01 EB002711-07/EB/NIBIB NIH HHS; R21 EB006860-02/EB/NIBIB NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 122795-43-1/gadodiamide; 7440-63-3/Xenon; 80529-93-7/Gadolinium DTPA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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