Document Detail


Improving cystine stone therapy: an in vitro study of dissolution.
MedLine Citation:
PMID:  10654887     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To perform an in vitro study analyzing the possibilities in therapeutic strategies for an effective treatment of cystine stones. METHODS: Artificial stones made of cystine [Bon(n)-Stones] with a ball-shaped size of 0.9 cm in diameter were used. Chemolysis of artificial cystine stones with different solvents (artificial urine, physiologic sodium chloride solution, acetylcysteine, tris-(hydroxymethylene)-aminomethane [THAM], and combinations of these) was investigated. An experimental arrangement with computer-assisted online measurement of data simulating the physiologic conditions in the upper urinary tract at varying pH values was used. RESULTS: All solutions showed a statistical improvement in the solubility of cystine stones compared with artificial urine and physiologic sodium chloride solution. The combination of THAM (pH 10) and 2% acetylcysteine was most effective (1 3.91 +/- 1.73 mg/hr) and demonstrated a 41 -fold higher ability to dissolve cystine calculi compared with artificial urine. CONCLUSIONS: Our data indicate that local chemolysis with special solutions is an effective treatment modality in cystine stone therapy.
Authors:
D Heimbach; D Jacobs; S C Müller; A Hesse
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Urology     Volume:  55     ISSN:  1527-9995     ISO Abbreviation:  Urology     Publication Date:  2000 Jan 
Date Detail:
Created Date:  2000-02-17     Completed Date:  2000-02-17     Revised Date:  2001-05-18    
Medline Journal Info:
Nlm Unique ID:  0366151     Medline TA:  Urology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  17-21     Citation Subset:  IM    
Affiliation:
Department of Urology, University of Bonn, Germany.
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MeSH Terms
Descriptor/Qualifier:
Acetylcysteine / pharmacology
Cystine / analysis*,  chemistry*
Sodium Chloride / pharmacology
Solubility
Time Factors
Tromethamine / pharmacology
Urinary Calculi / chemistry*,  drug therapy
Chemical
Reg. No./Substance:
56-89-3/Cystine; 616-91-1/Acetylcysteine; 7647-14-5/Sodium Chloride; 77-86-1/Tromethamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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