| Improving cystine stone therapy: an in vitro study of dissolution. | |
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MedLine Citation:
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PMID: 10654887 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To perform an in vitro study analyzing the possibilities in therapeutic strategies for an effective treatment of cystine stones. METHODS: Artificial stones made of cystine [Bon(n)-Stones] with a ball-shaped size of 0.9 cm in diameter were used. Chemolysis of artificial cystine stones with different solvents (artificial urine, physiologic sodium chloride solution, acetylcysteine, tris-(hydroxymethylene)-aminomethane [THAM], and combinations of these) was investigated. An experimental arrangement with computer-assisted online measurement of data simulating the physiologic conditions in the upper urinary tract at varying pH values was used. RESULTS: All solutions showed a statistical improvement in the solubility of cystine stones compared with artificial urine and physiologic sodium chloride solution. The combination of THAM (pH 10) and 2% acetylcysteine was most effective (1 3.91 +/- 1.73 mg/hr) and demonstrated a 41 -fold higher ability to dissolve cystine calculi compared with artificial urine. CONCLUSIONS: Our data indicate that local chemolysis with special solutions is an effective treatment modality in cystine stone therapy. |
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Authors:
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D Heimbach; D Jacobs; S C Müller; A Hesse |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Urology Volume: 55 ISSN: 1527-9995 ISO Abbreviation: Urology Publication Date: 2000 Jan |
Date Detail:
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Created Date: 2000-02-17 Completed Date: 2000-02-17 Revised Date: 2001-05-18 |
Medline Journal Info:
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Nlm Unique ID: 0366151 Medline TA: Urology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 17-21 Citation Subset: IM |
Affiliation:
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Department of Urology, University of Bonn, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcysteine
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pharmacology Cystine / analysis*, chemistry* Sodium Chloride / pharmacology Solubility Time Factors Tromethamine / pharmacology Urinary Calculi / chemistry*, drug therapy |
| Chemical | |
Reg. No./Substance:
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56-89-3/Cystine; 616-91-1/Acetylcysteine; 7647-14-5/Sodium Chloride; 77-86-1/Tromethamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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