| Improving anti-angiogenic therapy via selective delivery of cationic liposomes to tumour vasculature. | |
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MedLine Citation:
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PMID: 14602379 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the past three decades, two very important findings regarding tumour vasculature have been made. Firstly, it has been known a solid tumour has to establish an adequate blood supply to grow beyond a critical mass. Secondly, it has been proven that the tumour vasculature is relatively more aberrant, dynamic and permeable than healthy host tissue. This review discusses the potential of delivering therapeutic nucleic acids to tumour vasculature using cationic liposomes, vehicles recently demonstrated to be selectively delivered to tumour vasculature. |
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Authors:
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Crispin R Dass |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: International journal of pharmaceutics Volume: 267 ISSN: 0378-5173 ISO Abbreviation: Int J Pharm Publication Date: 2003 Nov |
Date Detail:
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Created Date: 2003-11-06 Completed Date: 2004-03-08 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7804127 Medline TA: Int J Pharm Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1-12 Citation Subset: IM |
Affiliation:
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Johnson & Johnson Research, Box 4555, Strawberry Hills 2012, Australia. crispin.dass@genetype.com.au |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angiogenesis Inhibitors
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administration & dosage*,
therapeutic use Animals Cations / metabolism Chemistry, Pharmaceutical Drug Carriers Drug Delivery Systems* Gene Therapy Gene Transfer Techniques Humans Liposomes / administration & dosage*, chemistry Neovascularization, Pathologic / metabolism, therapy* |
| Chemical | |
Reg. No./Substance:
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0/Angiogenesis Inhibitors; 0/Cations; 0/Drug Carriers; 0/Liposomes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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